Cargando…

Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study

The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on p...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Jiwon, Ryu, Jung-Hee, Koo, Bon-Wook, Nam, Sun Woo, Cho, Sang-Il, Oh, Ah-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230613/
https://www.ncbi.nlm.nih.gov/pubmed/32344750
http://dx.doi.org/10.3390/jcm9041232
_version_ 1783534995486277632
author Han, Jiwon
Ryu, Jung-Hee
Koo, Bon-Wook
Nam, Sun Woo
Cho, Sang-Il
Oh, Ah-Young
author_facet Han, Jiwon
Ryu, Jung-Hee
Koo, Bon-Wook
Nam, Sun Woo
Cho, Sang-Il
Oh, Ah-Young
author_sort Han, Jiwon
collection PubMed
description The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmonary complications in patients undergoing laparoscopic gastrectomy between 2013 and 2017. We performed propensity score matching to correct for selection bias. Post-operative pulmonary complications (i.e., pneumonia, respiratory failure, pleural effusion, atelectasis, pneumothorax, and aspiration pneumonitis) were evaluated from the radiological and laboratory findings. We also evaluated admission to the intensive care unit after surgery, re-admission or an emergency room visit within 30 days after discharge, length of hospital stay, re-operation, and mortality within 90 days post-operatively as secondary outcomes. In the initial cohort of 3802 patients, 541 patients were excluded, and 1232 patients were analyzed after propensity score matching. In the matched cohort, pleural effusion was significantly reduced in the sugammadex group compared to the neostigmine group (neostigmine 23.4% vs. sugammadex 18%, p = 0.02). Other pulmonary complications and secondary outcomes were not significantly different between the groups. In comparison to neostigmine, the use of sugammadex was associated with a lower incidence of post-operative pleural effusion in laparoscopic gastrectomy.
format Online
Article
Text
id pubmed-7230613
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72306132020-05-22 Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study Han, Jiwon Ryu, Jung-Hee Koo, Bon-Wook Nam, Sun Woo Cho, Sang-Il Oh, Ah-Young J Clin Med Article The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmonary complications in patients undergoing laparoscopic gastrectomy between 2013 and 2017. We performed propensity score matching to correct for selection bias. Post-operative pulmonary complications (i.e., pneumonia, respiratory failure, pleural effusion, atelectasis, pneumothorax, and aspiration pneumonitis) were evaluated from the radiological and laboratory findings. We also evaluated admission to the intensive care unit after surgery, re-admission or an emergency room visit within 30 days after discharge, length of hospital stay, re-operation, and mortality within 90 days post-operatively as secondary outcomes. In the initial cohort of 3802 patients, 541 patients were excluded, and 1232 patients were analyzed after propensity score matching. In the matched cohort, pleural effusion was significantly reduced in the sugammadex group compared to the neostigmine group (neostigmine 23.4% vs. sugammadex 18%, p = 0.02). Other pulmonary complications and secondary outcomes were not significantly different between the groups. In comparison to neostigmine, the use of sugammadex was associated with a lower incidence of post-operative pleural effusion in laparoscopic gastrectomy. MDPI 2020-04-24 /pmc/articles/PMC7230613/ /pubmed/32344750 http://dx.doi.org/10.3390/jcm9041232 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Jiwon
Ryu, Jung-Hee
Koo, Bon-Wook
Nam, Sun Woo
Cho, Sang-Il
Oh, Ah-Young
Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title_full Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title_fullStr Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title_full_unstemmed Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title_short Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
title_sort effects of sugammadex on post-operative pulmonary complications in laparoscopic gastrectomy: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230613/
https://www.ncbi.nlm.nih.gov/pubmed/32344750
http://dx.doi.org/10.3390/jcm9041232
work_keys_str_mv AT hanjiwon effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy
AT ryujunghee effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy
AT koobonwook effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy
AT namsunwoo effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy
AT chosangil effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy
AT ohahyoung effectsofsugammadexonpostoperativepulmonarycomplicationsinlaparoscopicgastrectomyaretrospectivecohortstudy