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The Skin Microbiota and Itch: Is There a Link?

Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings and the skin microbiota, relaying itch signals to the brain. Stress also exacerbate...

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Detalles Bibliográficos
Autores principales: Kim, Hei Sung, Yosipovitch, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230651/
https://www.ncbi.nlm.nih.gov/pubmed/32331207
http://dx.doi.org/10.3390/jcm9041190
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author Kim, Hei Sung
Yosipovitch, Gil
author_facet Kim, Hei Sung
Yosipovitch, Gil
author_sort Kim, Hei Sung
collection PubMed
description Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings and the skin microbiota, relaying itch signals to the brain. Stress also exacerbates itch via the skin–brain axis. Recently, the microbiota has surfaced as a major player to regulate this axis, notably during stress settings aroused by actual or perceived homeostatic challenge. The routes of communication between the microbiota and brain are slowly being unraveled and involve neurochemicals (i.e., acetylcholine, histamine, catecholamines, corticotropin) that originate from the microbiota itself. By focusing on itch biology and by referring to the more established field of pain research, this review examines the possible means by which the skin microbiota contributes to itch.
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spelling pubmed-72306512020-05-22 The Skin Microbiota and Itch: Is There a Link? Kim, Hei Sung Yosipovitch, Gil J Clin Med Review Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings and the skin microbiota, relaying itch signals to the brain. Stress also exacerbates itch via the skin–brain axis. Recently, the microbiota has surfaced as a major player to regulate this axis, notably during stress settings aroused by actual or perceived homeostatic challenge. The routes of communication between the microbiota and brain are slowly being unraveled and involve neurochemicals (i.e., acetylcholine, histamine, catecholamines, corticotropin) that originate from the microbiota itself. By focusing on itch biology and by referring to the more established field of pain research, this review examines the possible means by which the skin microbiota contributes to itch. MDPI 2020-04-22 /pmc/articles/PMC7230651/ /pubmed/32331207 http://dx.doi.org/10.3390/jcm9041190 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Hei Sung
Yosipovitch, Gil
The Skin Microbiota and Itch: Is There a Link?
title The Skin Microbiota and Itch: Is There a Link?
title_full The Skin Microbiota and Itch: Is There a Link?
title_fullStr The Skin Microbiota and Itch: Is There a Link?
title_full_unstemmed The Skin Microbiota and Itch: Is There a Link?
title_short The Skin Microbiota and Itch: Is There a Link?
title_sort skin microbiota and itch: is there a link?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230651/
https://www.ncbi.nlm.nih.gov/pubmed/32331207
http://dx.doi.org/10.3390/jcm9041190
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