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Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context

This review examines the current state of knowledge regarding toxins from anthozoans (sea anemones, coral, zoanthids, corallimorphs, sea pens and tube anemones). We provide an overview of venom from phylum Cnidaria and review the diversity of venom composition between the two major clades (Medusozoa...

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Autores principales: Ashwood, Lauren M., Norton, Raymond S., Undheim, Eivind A. B., Hurwood, David A., Prentis, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230708/
https://www.ncbi.nlm.nih.gov/pubmed/32283847
http://dx.doi.org/10.3390/md18040202
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author Ashwood, Lauren M.
Norton, Raymond S.
Undheim, Eivind A. B.
Hurwood, David A.
Prentis, Peter J.
author_facet Ashwood, Lauren M.
Norton, Raymond S.
Undheim, Eivind A. B.
Hurwood, David A.
Prentis, Peter J.
author_sort Ashwood, Lauren M.
collection PubMed
description This review examines the current state of knowledge regarding toxins from anthozoans (sea anemones, coral, zoanthids, corallimorphs, sea pens and tube anemones). We provide an overview of venom from phylum Cnidaria and review the diversity of venom composition between the two major clades (Medusozoa and Anthozoa). We highlight that the functional and ecological context of venom has implications for the temporal and spatial expression of protein and peptide toxins within class Anthozoa. Understanding the nuances in the regulation of venom arsenals has been made possible by recent advances in analytical technologies that allow characterisation of the spatial distributions of toxins. Furthermore, anthozoans are unique in that ecological roles can be assigned using tissue expression data, thereby circumventing some of the challenges related to pharmacological screening.
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spelling pubmed-72307082020-05-22 Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context Ashwood, Lauren M. Norton, Raymond S. Undheim, Eivind A. B. Hurwood, David A. Prentis, Peter J. Mar Drugs Review This review examines the current state of knowledge regarding toxins from anthozoans (sea anemones, coral, zoanthids, corallimorphs, sea pens and tube anemones). We provide an overview of venom from phylum Cnidaria and review the diversity of venom composition between the two major clades (Medusozoa and Anthozoa). We highlight that the functional and ecological context of venom has implications for the temporal and spatial expression of protein and peptide toxins within class Anthozoa. Understanding the nuances in the regulation of venom arsenals has been made possible by recent advances in analytical technologies that allow characterisation of the spatial distributions of toxins. Furthermore, anthozoans are unique in that ecological roles can be assigned using tissue expression data, thereby circumventing some of the challenges related to pharmacological screening. MDPI 2020-04-09 /pmc/articles/PMC7230708/ /pubmed/32283847 http://dx.doi.org/10.3390/md18040202 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ashwood, Lauren M.
Norton, Raymond S.
Undheim, Eivind A. B.
Hurwood, David A.
Prentis, Peter J.
Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title_full Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title_fullStr Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title_full_unstemmed Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title_short Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context
title_sort characterising functional venom profiles of anthozoans and medusozoans within their ecological context
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230708/
https://www.ncbi.nlm.nih.gov/pubmed/32283847
http://dx.doi.org/10.3390/md18040202
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