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Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy

Background: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. Methods: Children with OSA between ag...

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Autores principales: Huang, Yu-Shu, Chin, Wei-Chih, Guilleminault, Christian, Chu, Kuo-Chung, Lin, Cheng-Hui, Li, Hsueh-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230716/
https://www.ncbi.nlm.nih.gov/pubmed/32260590
http://dx.doi.org/10.3390/jcm9041028
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author Huang, Yu-Shu
Chin, Wei-Chih
Guilleminault, Christian
Chu, Kuo-Chung
Lin, Cheng-Hui
Li, Hsueh-Yu
author_facet Huang, Yu-Shu
Chin, Wei-Chih
Guilleminault, Christian
Chu, Kuo-Chung
Lin, Cheng-Hui
Li, Hsueh-Yu
author_sort Huang, Yu-Shu
collection PubMed
description Background: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. Methods: Children with OSA between age 4 and 12 receiving T&A were prospectively followed. Evaluation before and reevaluation six months after the treatment were done, including polysomnography (PSG), blood tests, and questionnaires. Blood samples were obtained to determine the values of high-sensitivity-C-reactive-protein (HS-CRP); tumor-necrosis-factor-alpha (TNF-α); and interleukin (IL)-1, 6, 10, 12, 17, and 23. We compared the results with an age-matched control group. Results: We included 55 OSA children and 32 controls. Children with OSA presented significant improvement after T&A in complaints, signs, apnea hypopnea index (AHI) (p < 0.001), mean oxygen desaturation index (p < 0.001), and mean oxygen saturation (p = 0.010). Upon entering this study, children with OSA had significantly higher cytokine levels than the controls and significant changes in HS-CRP (p = 0.013), TNF-α (p = 0.057), IL-1β (p = 0.022), IL-10 (p = 0.035), and IL-17 (p = 0.010) after T&A. Children with improved but persistently abnormal AHI did not have all cytokine levels normalized, particularly IL-23 and HS-CRP. Conclusion: Sleep-disordered breathing can persist after T&A and can continue to have a negative inflammatory effect. HS-CRP and IL-23 may serve as blood markers for the persistence of sleep-disordered breathing after T&A.
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spelling pubmed-72307162020-05-22 Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy Huang, Yu-Shu Chin, Wei-Chih Guilleminault, Christian Chu, Kuo-Chung Lin, Cheng-Hui Li, Hsueh-Yu J Clin Med Article Background: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. Methods: Children with OSA between age 4 and 12 receiving T&A were prospectively followed. Evaluation before and reevaluation six months after the treatment were done, including polysomnography (PSG), blood tests, and questionnaires. Blood samples were obtained to determine the values of high-sensitivity-C-reactive-protein (HS-CRP); tumor-necrosis-factor-alpha (TNF-α); and interleukin (IL)-1, 6, 10, 12, 17, and 23. We compared the results with an age-matched control group. Results: We included 55 OSA children and 32 controls. Children with OSA presented significant improvement after T&A in complaints, signs, apnea hypopnea index (AHI) (p < 0.001), mean oxygen desaturation index (p < 0.001), and mean oxygen saturation (p = 0.010). Upon entering this study, children with OSA had significantly higher cytokine levels than the controls and significant changes in HS-CRP (p = 0.013), TNF-α (p = 0.057), IL-1β (p = 0.022), IL-10 (p = 0.035), and IL-17 (p = 0.010) after T&A. Children with improved but persistently abnormal AHI did not have all cytokine levels normalized, particularly IL-23 and HS-CRP. Conclusion: Sleep-disordered breathing can persist after T&A and can continue to have a negative inflammatory effect. HS-CRP and IL-23 may serve as blood markers for the persistence of sleep-disordered breathing after T&A. MDPI 2020-04-05 /pmc/articles/PMC7230716/ /pubmed/32260590 http://dx.doi.org/10.3390/jcm9041028 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yu-Shu
Chin, Wei-Chih
Guilleminault, Christian
Chu, Kuo-Chung
Lin, Cheng-Hui
Li, Hsueh-Yu
Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title_full Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title_fullStr Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title_full_unstemmed Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title_short Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy
title_sort inflammatory factors: nonobese pediatric obstructive sleep apnea and adenotonsillectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230716/
https://www.ncbi.nlm.nih.gov/pubmed/32260590
http://dx.doi.org/10.3390/jcm9041028
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