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Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults

We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease...

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Autores principales: Zonneveld, Michelle H., Noordam, Raymond, van der Grond, Jeroen, Sabayan, Behnam, Mooijaart, Simon P., Mcfarlane, Peter W., Jukema, J. Wouter, Trompet, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230741/
https://www.ncbi.nlm.nih.gov/pubmed/32225080
http://dx.doi.org/10.3390/jcm9040911
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author Zonneveld, Michelle H.
Noordam, Raymond
van der Grond, Jeroen
Sabayan, Behnam
Mooijaart, Simon P.
Mcfarlane, Peter W.
Jukema, J. Wouter
Trompet, Stella
author_facet Zonneveld, Michelle H.
Noordam, Raymond
van der Grond, Jeroen
Sabayan, Behnam
Mooijaart, Simon P.
Mcfarlane, Peter W.
Jukema, J. Wouter
Trompet, Stella
author_sort Zonneveld, Michelle H.
collection PubMed
description We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were conducted at baseline. Cognitive function was tested at baseline and repeated during a mean follow-up time of 3.2 years. Structural MRIs were conducted in a subgroup of 535 participants. Analyses were performed with multivariable (repeated) linear regression models and adjusted for cardiovascular risk-factors, co-morbidities, and cardiovascular drug use. At baseline, longer QT, JT, JTc—but not QTc and QRS intervals—were associated with a worse cognitive performance. Most notably, on the Stroop Test, participants performed 3.02 (95% CI 0.31; 5.73) seconds worse per standard deviation higher QT interval, independent of cardiovascular risk factors and medication use. There was no association between longer ventricular de- or repolarization and structural brain measurements. Therefore, specifically ventricular repolarization was associated with worse cognitive performance in older individuals at baseline but not during follow-up.
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spelling pubmed-72307412020-05-22 Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults Zonneveld, Michelle H. Noordam, Raymond van der Grond, Jeroen Sabayan, Behnam Mooijaart, Simon P. Mcfarlane, Peter W. Jukema, J. Wouter Trompet, Stella J Clin Med Article We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were conducted at baseline. Cognitive function was tested at baseline and repeated during a mean follow-up time of 3.2 years. Structural MRIs were conducted in a subgroup of 535 participants. Analyses were performed with multivariable (repeated) linear regression models and adjusted for cardiovascular risk-factors, co-morbidities, and cardiovascular drug use. At baseline, longer QT, JT, JTc—but not QTc and QRS intervals—were associated with a worse cognitive performance. Most notably, on the Stroop Test, participants performed 3.02 (95% CI 0.31; 5.73) seconds worse per standard deviation higher QT interval, independent of cardiovascular risk factors and medication use. There was no association between longer ventricular de- or repolarization and structural brain measurements. Therefore, specifically ventricular repolarization was associated with worse cognitive performance in older individuals at baseline but not during follow-up. MDPI 2020-03-26 /pmc/articles/PMC7230741/ /pubmed/32225080 http://dx.doi.org/10.3390/jcm9040911 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zonneveld, Michelle H.
Noordam, Raymond
van der Grond, Jeroen
Sabayan, Behnam
Mooijaart, Simon P.
Mcfarlane, Peter W.
Jukema, J. Wouter
Trompet, Stella
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title_full Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title_fullStr Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title_full_unstemmed Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title_short Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
title_sort ventricular repolarization is associated with cognitive function, but not with cognitive decline and brain magnetic resonance imaging (mri) measurements in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230741/
https://www.ncbi.nlm.nih.gov/pubmed/32225080
http://dx.doi.org/10.3390/jcm9040911
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