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Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study

Background: Medication overuse headache (MOH) is a chronic pain syndrome that arises from the frequent use of acute antimigraine drugs. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with a possible therapeutic effect in this particular context. Methods:...

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Autores principales: Mansour, Anthony G., Ahdab, Rechdi, Khazen, Georges, El-Khoury, Christelle, Sabbouh, Toni M., Salem, Maher, Yamak, Wissam, Chalah, Moussa A., Ayache, Samar S., Riachi, Naji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230777/
https://www.ncbi.nlm.nih.gov/pubmed/32290078
http://dx.doi.org/10.3390/jcm9041075
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author Mansour, Anthony G.
Ahdab, Rechdi
Khazen, Georges
El-Khoury, Christelle
Sabbouh, Toni M.
Salem, Maher
Yamak, Wissam
Chalah, Moussa A.
Ayache, Samar S.
Riachi, Naji
author_facet Mansour, Anthony G.
Ahdab, Rechdi
Khazen, Georges
El-Khoury, Christelle
Sabbouh, Toni M.
Salem, Maher
Yamak, Wissam
Chalah, Moussa A.
Ayache, Samar S.
Riachi, Naji
author_sort Mansour, Anthony G.
collection PubMed
description Background: Medication overuse headache (MOH) is a chronic pain syndrome that arises from the frequent use of acute antimigraine drugs. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with a possible therapeutic effect in this particular context. Methods: This was a randomized, sham-controlled, cross-over study. Eighteen patients with MOH (17 women, age range: 20–38 years) received three sets of three consecutive daily sessions of tDCS: anodal tDCS over the prefrontal cortex, cathodal tDCS over the occipital cortex ipsilateral to the dominant side of migraine pain, and sham. The order in which the tDCS blocks were delivered was randomly defined based on a 1:1:1 ratio. Patients filled in a migraine diary that allowed recording of the pain intensity (visual analogue scale) and the daily consumption of analgesic pills from one week before to two weeks after each condition. Results: Both prefrontal and occipital tDCS lowered the total number of migraine days and the number of severe migraine days per week at week 1, but only the effects of occipital tDCS on these two outcomes lasted until week 2. Only occipital tDCS decreased the daily analgesic pills consumption, at weeks 1 and 2. Conclusion: Three consecutive days of cathodal occipital tDCS appear to improve the clinical outcomes in patients with MOH.
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spelling pubmed-72307772020-05-22 Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study Mansour, Anthony G. Ahdab, Rechdi Khazen, Georges El-Khoury, Christelle Sabbouh, Toni M. Salem, Maher Yamak, Wissam Chalah, Moussa A. Ayache, Samar S. Riachi, Naji J Clin Med Article Background: Medication overuse headache (MOH) is a chronic pain syndrome that arises from the frequent use of acute antimigraine drugs. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with a possible therapeutic effect in this particular context. Methods: This was a randomized, sham-controlled, cross-over study. Eighteen patients with MOH (17 women, age range: 20–38 years) received three sets of three consecutive daily sessions of tDCS: anodal tDCS over the prefrontal cortex, cathodal tDCS over the occipital cortex ipsilateral to the dominant side of migraine pain, and sham. The order in which the tDCS blocks were delivered was randomly defined based on a 1:1:1 ratio. Patients filled in a migraine diary that allowed recording of the pain intensity (visual analogue scale) and the daily consumption of analgesic pills from one week before to two weeks after each condition. Results: Both prefrontal and occipital tDCS lowered the total number of migraine days and the number of severe migraine days per week at week 1, but only the effects of occipital tDCS on these two outcomes lasted until week 2. Only occipital tDCS decreased the daily analgesic pills consumption, at weeks 1 and 2. Conclusion: Three consecutive days of cathodal occipital tDCS appear to improve the clinical outcomes in patients with MOH. MDPI 2020-04-10 /pmc/articles/PMC7230777/ /pubmed/32290078 http://dx.doi.org/10.3390/jcm9041075 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mansour, Anthony G.
Ahdab, Rechdi
Khazen, Georges
El-Khoury, Christelle
Sabbouh, Toni M.
Salem, Maher
Yamak, Wissam
Chalah, Moussa A.
Ayache, Samar S.
Riachi, Naji
Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title_full Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title_fullStr Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title_full_unstemmed Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title_short Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study
title_sort transcranial direct current stimulation of the occipital cortex in medication overuse headache: a pilot randomized controlled cross-over study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230777/
https://www.ncbi.nlm.nih.gov/pubmed/32290078
http://dx.doi.org/10.3390/jcm9041075
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