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MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of n...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230865/ https://www.ncbi.nlm.nih.gov/pubmed/32231147 http://dx.doi.org/10.3390/jcm9040934 |
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author | Diamanti, Luca Paoletti, Matteo Di Vita, Umberto Muzic, Shaun Ivan Cereda, Cristina Ballante, Elena Pichiecchio, Anna |
author_facet | Diamanti, Luca Paoletti, Matteo Di Vita, Umberto Muzic, Shaun Ivan Cereda, Cristina Ballante, Elena Pichiecchio, Anna |
author_sort | Diamanti, Luca |
collection | PubMed |
description | Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker. |
format | Online Article Text |
id | pubmed-7230865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72308652020-05-22 MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) Diamanti, Luca Paoletti, Matteo Di Vita, Umberto Muzic, Shaun Ivan Cereda, Cristina Ballante, Elena Pichiecchio, Anna J Clin Med Article Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker. MDPI 2020-03-28 /pmc/articles/PMC7230865/ /pubmed/32231147 http://dx.doi.org/10.3390/jcm9040934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Diamanti, Luca Paoletti, Matteo Di Vita, Umberto Muzic, Shaun Ivan Cereda, Cristina Ballante, Elena Pichiecchio, Anna MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title | MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title_full | MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title_fullStr | MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title_full_unstemmed | MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title_short | MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) |
title_sort | mri study of paraspinal muscles in patients with amyotrophic lateral sclerosis (als) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230865/ https://www.ncbi.nlm.nih.gov/pubmed/32231147 http://dx.doi.org/10.3390/jcm9040934 |
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