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MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)

Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of n...

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Autores principales: Diamanti, Luca, Paoletti, Matteo, Di Vita, Umberto, Muzic, Shaun Ivan, Cereda, Cristina, Ballante, Elena, Pichiecchio, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230865/
https://www.ncbi.nlm.nih.gov/pubmed/32231147
http://dx.doi.org/10.3390/jcm9040934
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author Diamanti, Luca
Paoletti, Matteo
Di Vita, Umberto
Muzic, Shaun Ivan
Cereda, Cristina
Ballante, Elena
Pichiecchio, Anna
author_facet Diamanti, Luca
Paoletti, Matteo
Di Vita, Umberto
Muzic, Shaun Ivan
Cereda, Cristina
Ballante, Elena
Pichiecchio, Anna
author_sort Diamanti, Luca
collection PubMed
description Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker.
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spelling pubmed-72308652020-05-22 MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS) Diamanti, Luca Paoletti, Matteo Di Vita, Umberto Muzic, Shaun Ivan Cereda, Cristina Ballante, Elena Pichiecchio, Anna J Clin Med Article Background: the study of paraspinal muscles is pivotal for the diagnosis and staging of Amyotrophic Lateral Sclerosis (ALS), and is usually performed by electromyography. Objective: to evaluate the role of paraspinal muscle MRI as a diagnostic biomarker in ALS. Methods: we evaluated T1-w images of newly diagnosed ALS patients (n = 14), age-matched healthy controls (n = 11), patients affected by inflammatory myopathy (n = 10), and lumbar radiculopathy (n = 19), and compared them semiquantitatively by using the Mercuri Scale. Results: a significant difference in the appearance of the psoas muscle was observed between ALS patients and patients with radiculopathy (p = 0.003); after stratifying ALS patients into spinal and bulbar onsets, we found a significant difference in the appearance of the longissimus dorsi muscle between the spinal onset ALS subgroup and bulbar onset ALS subgroup (p = 0.0245), while no difference was found for multifidus (p = 0.1441), iliocostal (p = 0.0655), and psoas muscles (p = 0.0813) between the cohort subgroups. Conclusions: paraspinal T1-w MRI could help to distinguish spinal ALS patients from healthy and pathological controls. Specifically, the study of longissimus dorsi could play the role of a diagnostic ALS biomarker. MDPI 2020-03-28 /pmc/articles/PMC7230865/ /pubmed/32231147 http://dx.doi.org/10.3390/jcm9040934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diamanti, Luca
Paoletti, Matteo
Di Vita, Umberto
Muzic, Shaun Ivan
Cereda, Cristina
Ballante, Elena
Pichiecchio, Anna
MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title_full MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title_fullStr MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title_full_unstemmed MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title_short MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
title_sort mri study of paraspinal muscles in patients with amyotrophic lateral sclerosis (als)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230865/
https://www.ncbi.nlm.nih.gov/pubmed/32231147
http://dx.doi.org/10.3390/jcm9040934
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