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Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disab...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230935/ https://www.ncbi.nlm.nih.gov/pubmed/32325753 http://dx.doi.org/10.3390/jcm9041163 |
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author | Guillán-Fresco, María Franco-Trepat, Eloi Alonso-Pérez, Ana Jorge-Mora, Alberto López-Fagúndez, Miriam Pazos-Pérez, Andrés Gualillo, Oreste Gómez, Rodolfo |
author_facet | Guillán-Fresco, María Franco-Trepat, Eloi Alonso-Pérez, Ana Jorge-Mora, Alberto López-Fagúndez, Miriam Pazos-Pérez, Andrés Gualillo, Oreste Gómez, Rodolfo |
author_sort | Guillán-Fresco, María |
collection | PubMed |
description | Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies. |
format | Online Article Text |
id | pubmed-7230935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72309352020-05-22 Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition Guillán-Fresco, María Franco-Trepat, Eloi Alonso-Pérez, Ana Jorge-Mora, Alberto López-Fagúndez, Miriam Pazos-Pérez, Andrés Gualillo, Oreste Gómez, Rodolfo J Clin Med Review Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies. MDPI 2020-04-18 /pmc/articles/PMC7230935/ /pubmed/32325753 http://dx.doi.org/10.3390/jcm9041163 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guillán-Fresco, María Franco-Trepat, Eloi Alonso-Pérez, Ana Jorge-Mora, Alberto López-Fagúndez, Miriam Pazos-Pérez, Andrés Gualillo, Oreste Gómez, Rodolfo Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title | Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title_full | Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title_fullStr | Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title_full_unstemmed | Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title_short | Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition |
title_sort | caffeine, a risk factor for osteoarthritis and longitudinal bone growth inhibition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230935/ https://www.ncbi.nlm.nih.gov/pubmed/32325753 http://dx.doi.org/10.3390/jcm9041163 |
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