Cargando…

Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition

Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disab...

Descripción completa

Detalles Bibliográficos
Autores principales: Guillán-Fresco, María, Franco-Trepat, Eloi, Alonso-Pérez, Ana, Jorge-Mora, Alberto, López-Fagúndez, Miriam, Pazos-Pérez, Andrés, Gualillo, Oreste, Gómez, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230935/
https://www.ncbi.nlm.nih.gov/pubmed/32325753
http://dx.doi.org/10.3390/jcm9041163
_version_ 1783535073538080768
author Guillán-Fresco, María
Franco-Trepat, Eloi
Alonso-Pérez, Ana
Jorge-Mora, Alberto
López-Fagúndez, Miriam
Pazos-Pérez, Andrés
Gualillo, Oreste
Gómez, Rodolfo
author_facet Guillán-Fresco, María
Franco-Trepat, Eloi
Alonso-Pérez, Ana
Jorge-Mora, Alberto
López-Fagúndez, Miriam
Pazos-Pérez, Andrés
Gualillo, Oreste
Gómez, Rodolfo
author_sort Guillán-Fresco, María
collection PubMed
description Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies.
format Online
Article
Text
id pubmed-7230935
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72309352020-05-22 Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition Guillán-Fresco, María Franco-Trepat, Eloi Alonso-Pérez, Ana Jorge-Mora, Alberto López-Fagúndez, Miriam Pazos-Pérez, Andrés Gualillo, Oreste Gómez, Rodolfo J Clin Med Review Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies. MDPI 2020-04-18 /pmc/articles/PMC7230935/ /pubmed/32325753 http://dx.doi.org/10.3390/jcm9041163 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guillán-Fresco, María
Franco-Trepat, Eloi
Alonso-Pérez, Ana
Jorge-Mora, Alberto
López-Fagúndez, Miriam
Pazos-Pérez, Andrés
Gualillo, Oreste
Gómez, Rodolfo
Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title_full Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title_fullStr Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title_full_unstemmed Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title_short Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition
title_sort caffeine, a risk factor for osteoarthritis and longitudinal bone growth inhibition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230935/
https://www.ncbi.nlm.nih.gov/pubmed/32325753
http://dx.doi.org/10.3390/jcm9041163
work_keys_str_mv AT guillanfrescomaria caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT francotrepateloi caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT alonsoperezana caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT jorgemoraalberto caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT lopezfagundezmiriam caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT pazosperezandres caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT gualillooreste caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition
AT gomezrodolfo caffeineariskfactorforosteoarthritisandlongitudinalbonegrowthinhibition