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Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as...

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Autores principales: Jang, Yunseon, Lee, Jae Hyeon, Lee, Min Joung, Kim, Soo Jeong, Ju, Xianshu, Cui, Jianchen, Zhu, Jiebo, Lee, Yu Lim, Namgung, Eunji, Sung, Han Wool John, Lee, Hong Won, Ryu, Min Jeong, Oh, Eungseok, Chung, Woosuk, Kweon, Gi Ryang, Choi, Chun Whan, Heo, Jun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230947/
https://www.ncbi.nlm.nih.gov/pubmed/32218327
http://dx.doi.org/10.3390/nu12040897
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author Jang, Yunseon
Lee, Jae Hyeon
Lee, Min Joung
Kim, Soo Jeong
Ju, Xianshu
Cui, Jianchen
Zhu, Jiebo
Lee, Yu Lim
Namgung, Eunji
Sung, Han Wool John
Lee, Hong Won
Ryu, Min Jeong
Oh, Eungseok
Chung, Woosuk
Kweon, Gi Ryang
Choi, Chun Whan
Heo, Jun Young
author_facet Jang, Yunseon
Lee, Jae Hyeon
Lee, Min Joung
Kim, Soo Jeong
Ju, Xianshu
Cui, Jianchen
Zhu, Jiebo
Lee, Yu Lim
Namgung, Eunji
Sung, Han Wool John
Lee, Hong Won
Ryu, Min Jeong
Oh, Eungseok
Chung, Woosuk
Kweon, Gi Ryang
Choi, Chun Whan
Heo, Jun Young
author_sort Jang, Yunseon
collection PubMed
description Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline.
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spelling pubmed-72309472020-05-22 Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration Jang, Yunseon Lee, Jae Hyeon Lee, Min Joung Kim, Soo Jeong Ju, Xianshu Cui, Jianchen Zhu, Jiebo Lee, Yu Lim Namgung, Eunji Sung, Han Wool John Lee, Hong Won Ryu, Min Jeong Oh, Eungseok Chung, Woosuk Kweon, Gi Ryang Choi, Chun Whan Heo, Jun Young Nutrients Article Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline. MDPI 2020-03-25 /pmc/articles/PMC7230947/ /pubmed/32218327 http://dx.doi.org/10.3390/nu12040897 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jang, Yunseon
Lee, Jae Hyeon
Lee, Min Joung
Kim, Soo Jeong
Ju, Xianshu
Cui, Jianchen
Zhu, Jiebo
Lee, Yu Lim
Namgung, Eunji
Sung, Han Wool John
Lee, Hong Won
Ryu, Min Jeong
Oh, Eungseok
Chung, Woosuk
Kweon, Gi Ryang
Choi, Chun Whan
Heo, Jun Young
Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title_full Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title_fullStr Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title_full_unstemmed Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title_short Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration
title_sort schisandra extract and ascorbic acid synergistically enhance cognition in mice through modulation of mitochondrial respiration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230947/
https://www.ncbi.nlm.nih.gov/pubmed/32218327
http://dx.doi.org/10.3390/nu12040897
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