Cargando…

The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration

Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopat...

Descripción completa

Detalles Bibliográficos
Autores principales: Grewal, Nimrat, Gittenberger-de Groot, Adriana C., von der Thusen, Jan, Wisse, Lambertus J., Bartelings, Margot M., DeRuiter, Marco C., Klautz, Robert J.M., Poelmann, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230962/
https://www.ncbi.nlm.nih.gov/pubmed/32225051
http://dx.doi.org/10.3390/jcm9040908
_version_ 1783535080131526656
author Grewal, Nimrat
Gittenberger-de Groot, Adriana C.
von der Thusen, Jan
Wisse, Lambertus J.
Bartelings, Margot M.
DeRuiter, Marco C.
Klautz, Robert J.M.
Poelmann, Robert E.
author_facet Grewal, Nimrat
Gittenberger-de Groot, Adriana C.
von der Thusen, Jan
Wisse, Lambertus J.
Bartelings, Margot M.
DeRuiter, Marco C.
Klautz, Robert J.M.
Poelmann, Robert E.
author_sort Grewal, Nimrat
collection PubMed
description Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic–70 years) and 32 BAV specimens (fetal–72 years, categorized in eight age groups. Results: In TAV, intimal development starts in the neonatal phase. After birth, the thickness of the medial layer increases significantly by increase of elastic lamellae up to and including the “young child” phase stabilizing afterwards. The BAV shows already prenatal intimal thickening becoming significantly thinner after birth subsequently stabilizing. In BAV, increase in elastic lamellae is seen between the young child and the adolescent phases, stabilizing afterwards. Conclusions: Vascular development in TAV is described in three phases: maturation, stabilization, and degeneration. For BAV, the development can be described in two phases: maturation (already prenatally) and degeneration. After birth, the development of the aorta is characterized by degeneration, leading to weakening of the ascending aortic wall and increasing the risk of aortopathy.
format Online
Article
Text
id pubmed-7230962
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72309622020-05-22 The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration Grewal, Nimrat Gittenberger-de Groot, Adriana C. von der Thusen, Jan Wisse, Lambertus J. Bartelings, Margot M. DeRuiter, Marco C. Klautz, Robert J.M. Poelmann, Robert E. J Clin Med Article Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic–70 years) and 32 BAV specimens (fetal–72 years, categorized in eight age groups. Results: In TAV, intimal development starts in the neonatal phase. After birth, the thickness of the medial layer increases significantly by increase of elastic lamellae up to and including the “young child” phase stabilizing afterwards. The BAV shows already prenatal intimal thickening becoming significantly thinner after birth subsequently stabilizing. In BAV, increase in elastic lamellae is seen between the young child and the adolescent phases, stabilizing afterwards. Conclusions: Vascular development in TAV is described in three phases: maturation, stabilization, and degeneration. For BAV, the development can be described in two phases: maturation (already prenatally) and degeneration. After birth, the development of the aorta is characterized by degeneration, leading to weakening of the ascending aortic wall and increasing the risk of aortopathy. MDPI 2020-03-26 /pmc/articles/PMC7230962/ /pubmed/32225051 http://dx.doi.org/10.3390/jcm9040908 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grewal, Nimrat
Gittenberger-de Groot, Adriana C.
von der Thusen, Jan
Wisse, Lambertus J.
Bartelings, Margot M.
DeRuiter, Marco C.
Klautz, Robert J.M.
Poelmann, Robert E.
The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title_full The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title_fullStr The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title_full_unstemmed The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title_short The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration
title_sort development of the ascending aortic wall in tricuspid and bicuspid aortic valve: a process from maturation to degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230962/
https://www.ncbi.nlm.nih.gov/pubmed/32225051
http://dx.doi.org/10.3390/jcm9040908
work_keys_str_mv AT grewalnimrat thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT gittenbergerdegrootadrianac thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT vonderthusenjan thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT wisselambertusj thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT bartelingsmargotm thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT deruitermarcoc thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT klautzrobertjm thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT poelmannroberte thedevelopmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT grewalnimrat developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT gittenbergerdegrootadrianac developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT vonderthusenjan developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT wisselambertusj developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT bartelingsmargotm developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT deruitermarcoc developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT klautzrobertjm developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration
AT poelmannroberte developmentoftheascendingaorticwallintricuspidandbicuspidaorticvalveaprocessfrommaturationtodegeneration