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Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study

Background: Despite the robust data available on inflammatory indices (neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)) and clinical outcome in oncological patients, their utility as a predictor of cancer incidence in the general popul...

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Autores principales: Rimini, Margherita, Casadei-Gardini, Andrea, Ravaioli, Alessandra, Rovesti, Giulia, Conti, Fabio, Borghi, Alberto, Dall’Aglio, Anna Chiara, Bedogni, Giorgio, Domenicali, Marco, Giacomoni, Pierluigi, Tiribelli, Claudio, Bucchi, Lauro, Falcini, Fabio, Foschi, Francesco Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231063/
https://www.ncbi.nlm.nih.gov/pubmed/32325965
http://dx.doi.org/10.3390/jcm9041177
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author Rimini, Margherita
Casadei-Gardini, Andrea
Ravaioli, Alessandra
Rovesti, Giulia
Conti, Fabio
Borghi, Alberto
Dall’Aglio, Anna Chiara
Bedogni, Giorgio
Domenicali, Marco
Giacomoni, Pierluigi
Tiribelli, Claudio
Bucchi, Lauro
Falcini, Fabio
Foschi, Francesco Giuseppe
author_facet Rimini, Margherita
Casadei-Gardini, Andrea
Ravaioli, Alessandra
Rovesti, Giulia
Conti, Fabio
Borghi, Alberto
Dall’Aglio, Anna Chiara
Bedogni, Giorgio
Domenicali, Marco
Giacomoni, Pierluigi
Tiribelli, Claudio
Bucchi, Lauro
Falcini, Fabio
Foschi, Francesco Giuseppe
author_sort Rimini, Margherita
collection PubMed
description Background: Despite the robust data available on inflammatory indices (neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)) and clinical outcome in oncological patients, their utility as a predictor of cancer incidence in the general population has not been reported in literature. Methods: The Bagnacavallo study was performed between October 2005 and March 2009. All citizens of Bagnacavallo (Ravenna, Emilia-Romagna, Italy) aged 30–60 years as of January 2005 were eligible and were invited by written letter to participate to the study. All participants underwent a detailed clinical history and physical examination following the model of the Dionysos Study. All blood values included in the analysis were obtained the day of physical examination. Cancer incidence data were obtained from the population-based Romagna Cancer Registry, which operates according to standard methods. The aim of this analysis was to examine the association between metabolic syndrome and baseline SII, NLR, and PLR levels, and the diagnosis of an invasive cancer in the Bagnacavallo study cohort. Results: At univariate analysis, metabolic syndrome was not associated with an increase of cancer incidence (HR 1.30; p = 0.155). High glucose (HR 1.49; p = 0.0.16), NLR HR 1.54, p = 0.002), PLR (HR 1.58, p = 0.001), and SII (HR 1.47, p = 0.006) were associated with an increase of cancer incidence. After adjusting for clinical covariates (smoking, physical activity, education, age, and gender) SII, PLR, and NLR remained independent prognostic factors for the prediction of cancer incidence. Conclusions: Inflammatory indices are promising, easy to perform, and inexpensive tools for identifying patients with higher risk of cancer in cancer-free population.
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spelling pubmed-72310632020-05-22 Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study Rimini, Margherita Casadei-Gardini, Andrea Ravaioli, Alessandra Rovesti, Giulia Conti, Fabio Borghi, Alberto Dall’Aglio, Anna Chiara Bedogni, Giorgio Domenicali, Marco Giacomoni, Pierluigi Tiribelli, Claudio Bucchi, Lauro Falcini, Fabio Foschi, Francesco Giuseppe J Clin Med Article Background: Despite the robust data available on inflammatory indices (neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)) and clinical outcome in oncological patients, their utility as a predictor of cancer incidence in the general population has not been reported in literature. Methods: The Bagnacavallo study was performed between October 2005 and March 2009. All citizens of Bagnacavallo (Ravenna, Emilia-Romagna, Italy) aged 30–60 years as of January 2005 were eligible and were invited by written letter to participate to the study. All participants underwent a detailed clinical history and physical examination following the model of the Dionysos Study. All blood values included in the analysis were obtained the day of physical examination. Cancer incidence data were obtained from the population-based Romagna Cancer Registry, which operates according to standard methods. The aim of this analysis was to examine the association between metabolic syndrome and baseline SII, NLR, and PLR levels, and the diagnosis of an invasive cancer in the Bagnacavallo study cohort. Results: At univariate analysis, metabolic syndrome was not associated with an increase of cancer incidence (HR 1.30; p = 0.155). High glucose (HR 1.49; p = 0.0.16), NLR HR 1.54, p = 0.002), PLR (HR 1.58, p = 0.001), and SII (HR 1.47, p = 0.006) were associated with an increase of cancer incidence. After adjusting for clinical covariates (smoking, physical activity, education, age, and gender) SII, PLR, and NLR remained independent prognostic factors for the prediction of cancer incidence. Conclusions: Inflammatory indices are promising, easy to perform, and inexpensive tools for identifying patients with higher risk of cancer in cancer-free population. MDPI 2020-04-20 /pmc/articles/PMC7231063/ /pubmed/32325965 http://dx.doi.org/10.3390/jcm9041177 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rimini, Margherita
Casadei-Gardini, Andrea
Ravaioli, Alessandra
Rovesti, Giulia
Conti, Fabio
Borghi, Alberto
Dall’Aglio, Anna Chiara
Bedogni, Giorgio
Domenicali, Marco
Giacomoni, Pierluigi
Tiribelli, Claudio
Bucchi, Lauro
Falcini, Fabio
Foschi, Francesco Giuseppe
Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title_full Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title_fullStr Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title_full_unstemmed Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title_short Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
title_sort could inflammatory indices and metabolic syndrome predict the risk of cancer development? analysis from the bagnacavallo population study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231063/
https://www.ncbi.nlm.nih.gov/pubmed/32325965
http://dx.doi.org/10.3390/jcm9041177
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