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Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk

Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the re...

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Autores principales: Tasić, Ivan, Kostić, Svetlana, Stojanović, Nikola M., Djordjević, Dragan, Bogdanović, Dragan, Deljanin Ilić, Marina, Lović, Milan, Stoičkov, Viktor, Aleksandrić, Srdjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231082/
https://www.ncbi.nlm.nih.gov/pubmed/32316090
http://dx.doi.org/10.3390/medicina56040182
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author Tasić, Ivan
Kostić, Svetlana
Stojanović, Nikola M.
Djordjević, Dragan
Bogdanović, Dragan
Deljanin Ilić, Marina
Lović, Milan
Stoičkov, Viktor
Aleksandrić, Srdjan
author_facet Tasić, Ivan
Kostić, Svetlana
Stojanović, Nikola M.
Djordjević, Dragan
Bogdanović, Dragan
Deljanin Ilić, Marina
Lović, Milan
Stoičkov, Viktor
Aleksandrić, Srdjan
author_sort Tasić, Ivan
collection PubMed
description Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the reduction of all preexisting modifiable risk factors, prevention of target organs damage, and adverse cardiovascular events. The aim of this study was to determine independent predictors of cardiovascular events in patients with hypertension and high cardiovascular (CV) risk, and whether the modifiable risk factors could affect long-term prognosis in the studied population. Materials and Methods: This prospective study included 142 hypertensive patients (65% females), mean age 63.1±8 years, with high CV risk. Each participant was followed for 6.2 years. Results: During the follow-up period, the incidence of non-fatal and fatal CV events was 19.7%, CV mortality 7%, and total mortality 9.9%. Our multivariate analysis showed that plaques in both carotid arteries (p = 0.042), diabetes mellitus (p = 0.042) and cholesterol at the beginning of the study (p = 0.016) were significantly associated with an increased risk of CV events. Patients’ age (p = 0.009), intima-media thickness (p = 0.001) and diabetes mellitus (p = 0.042) were significantly associated with an increased risk of CV mortality, and age (p = 0.007) and cholesterol (p = 0.002) were independent variables significantly associated with increased total mortality rates. Conclusions: The results of the present study showed that the main predictors of adverse CV events in high-risk hypertensive patients were years of age, cholesterol levels, diabetes, intima-media thickness, and carotid arteries plaques.
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spelling pubmed-72310822020-05-22 Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk Tasić, Ivan Kostić, Svetlana Stojanović, Nikola M. Djordjević, Dragan Bogdanović, Dragan Deljanin Ilić, Marina Lović, Milan Stoičkov, Viktor Aleksandrić, Srdjan Medicina (Kaunas) Article Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the reduction of all preexisting modifiable risk factors, prevention of target organs damage, and adverse cardiovascular events. The aim of this study was to determine independent predictors of cardiovascular events in patients with hypertension and high cardiovascular (CV) risk, and whether the modifiable risk factors could affect long-term prognosis in the studied population. Materials and Methods: This prospective study included 142 hypertensive patients (65% females), mean age 63.1±8 years, with high CV risk. Each participant was followed for 6.2 years. Results: During the follow-up period, the incidence of non-fatal and fatal CV events was 19.7%, CV mortality 7%, and total mortality 9.9%. Our multivariate analysis showed that plaques in both carotid arteries (p = 0.042), diabetes mellitus (p = 0.042) and cholesterol at the beginning of the study (p = 0.016) were significantly associated with an increased risk of CV events. Patients’ age (p = 0.009), intima-media thickness (p = 0.001) and diabetes mellitus (p = 0.042) were significantly associated with an increased risk of CV mortality, and age (p = 0.007) and cholesterol (p = 0.002) were independent variables significantly associated with increased total mortality rates. Conclusions: The results of the present study showed that the main predictors of adverse CV events in high-risk hypertensive patients were years of age, cholesterol levels, diabetes, intima-media thickness, and carotid arteries plaques. MDPI 2020-04-16 /pmc/articles/PMC7231082/ /pubmed/32316090 http://dx.doi.org/10.3390/medicina56040182 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tasić, Ivan
Kostić, Svetlana
Stojanović, Nikola M.
Djordjević, Dragan
Bogdanović, Dragan
Deljanin Ilić, Marina
Lović, Milan
Stoičkov, Viktor
Aleksandrić, Srdjan
Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title_full Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title_fullStr Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title_full_unstemmed Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title_short Predictors of Cardiovascular Events in Hypertensive Patients with High Cardiovascular Risk
title_sort predictors of cardiovascular events in hypertensive patients with high cardiovascular risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231082/
https://www.ncbi.nlm.nih.gov/pubmed/32316090
http://dx.doi.org/10.3390/medicina56040182
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