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Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe...

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Autores principales: Medeiros R. de Magalhães, Cristina, Coutinho de Almeida, Fernanda, Gandolfi, Lenora, Pratesi, Riccardo, Ribeiro de M. Alves, Natália, Selleski, Nicole, Zandonadi, Renata Puppin, Nakano, Eduardo Yoshio, Pratesi, Claudia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231131/
https://www.ncbi.nlm.nih.gov/pubmed/32218369
http://dx.doi.org/10.3390/medicina56040145
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author Medeiros R. de Magalhães, Cristina
Coutinho de Almeida, Fernanda
Gandolfi, Lenora
Pratesi, Riccardo
Ribeiro de M. Alves, Natália
Selleski, Nicole
Zandonadi, Renata Puppin
Nakano, Eduardo Yoshio
Pratesi, Claudia B.
author_facet Medeiros R. de Magalhães, Cristina
Coutinho de Almeida, Fernanda
Gandolfi, Lenora
Pratesi, Riccardo
Ribeiro de M. Alves, Natália
Selleski, Nicole
Zandonadi, Renata Puppin
Nakano, Eduardo Yoshio
Pratesi, Claudia B.
author_sort Medeiros R. de Magalhães, Cristina
collection PubMed
description Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe and correlate the clinical features of this disorder with the children’s age at the time of disease onset, (3) to correlate the frequent lack of early diagnosis with a delayed application of appropriate treatment, and (4) to describe the outcome and eventual recurrences of KD in our region. Materials and Methods: Three hundred and one participants (183 males and 118 females) included in the study were diagnosed and, subsequently, clinically followed for ten years (January 2007 to December 2016) at the Pediatric Rheumatology Walk-in Clinic of the Children’s Hospital of Brasilia. Results: Episodes ranged from four months to two years. This rate of recurrence was well-above that disclosed by previous reports. Delay in diagnosis, in all age groups, caused an undesirable delay between the disease onset, the final diagnosis, and the administration of intravenous immunoglobulin (IVIG). KD recurred in 25 (8.3%) of the children during the first three years of follow-up. In seven patients, KD recurred twice, with an interval between episodes ranging from four months to two years. Conclusions: This rate of recurrence was well-above that disclosed by previous reports. In Latin America, aside from a handful of physicians and researchers, KD is being ignored. There is a pressing need to educate primary health care physicians and bring awareness to the fact that KD is not an exotic condition that affects only the Asian populations but a disorder that already exists among us and that frequently results in severe consequences.
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spelling pubmed-72311312020-05-22 Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study Medeiros R. de Magalhães, Cristina Coutinho de Almeida, Fernanda Gandolfi, Lenora Pratesi, Riccardo Ribeiro de M. Alves, Natália Selleski, Nicole Zandonadi, Renata Puppin Nakano, Eduardo Yoshio Pratesi, Claudia B. Medicina (Kaunas) Article Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe and correlate the clinical features of this disorder with the children’s age at the time of disease onset, (3) to correlate the frequent lack of early diagnosis with a delayed application of appropriate treatment, and (4) to describe the outcome and eventual recurrences of KD in our region. Materials and Methods: Three hundred and one participants (183 males and 118 females) included in the study were diagnosed and, subsequently, clinically followed for ten years (January 2007 to December 2016) at the Pediatric Rheumatology Walk-in Clinic of the Children’s Hospital of Brasilia. Results: Episodes ranged from four months to two years. This rate of recurrence was well-above that disclosed by previous reports. Delay in diagnosis, in all age groups, caused an undesirable delay between the disease onset, the final diagnosis, and the administration of intravenous immunoglobulin (IVIG). KD recurred in 25 (8.3%) of the children during the first three years of follow-up. In seven patients, KD recurred twice, with an interval between episodes ranging from four months to two years. Conclusions: This rate of recurrence was well-above that disclosed by previous reports. In Latin America, aside from a handful of physicians and researchers, KD is being ignored. There is a pressing need to educate primary health care physicians and bring awareness to the fact that KD is not an exotic condition that affects only the Asian populations but a disorder that already exists among us and that frequently results in severe consequences. MDPI 2020-03-25 /pmc/articles/PMC7231131/ /pubmed/32218369 http://dx.doi.org/10.3390/medicina56040145 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Medeiros R. de Magalhães, Cristina
Coutinho de Almeida, Fernanda
Gandolfi, Lenora
Pratesi, Riccardo
Ribeiro de M. Alves, Natália
Selleski, Nicole
Zandonadi, Renata Puppin
Nakano, Eduardo Yoshio
Pratesi, Claudia B.
Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title_full Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title_fullStr Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title_full_unstemmed Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title_short Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study
title_sort clinical manifestations of kawasaki disease at different age spectrum: a ten-year study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231131/
https://www.ncbi.nlm.nih.gov/pubmed/32218369
http://dx.doi.org/10.3390/medicina56040145
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