11β,20β-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Two 11,20-epoxybriaranes, including a known compound, juncenolide K (1), as well as a new metabolite, fragilide X (2), have been isolated from gorgonian Junceella fragilis collected off the waters of Taiwan. The absolute configuration of juncenolide K (1) was determined by single-crystal X-ray diffr...

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Detalles Bibliográficos
Autores principales: Su, Tung-Pin, Kuo, Tsu-Jen, Yang, San-Nan, Lee, Gene-Hsiang, Lee, Yen-Tung, Wang, Yi-Chen, Chen, Jih-Jung, Wen, Zhi-Hong, Hwang, Tsong-Long, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231240/
https://www.ncbi.nlm.nih.gov/pubmed/32244363
http://dx.doi.org/10.3390/md18040183
Descripción
Sumario:Two 11,20-epoxybriaranes, including a known compound, juncenolide K (1), as well as a new metabolite, fragilide X (2), have been isolated from gorgonian Junceella fragilis collected off the waters of Taiwan. The absolute configuration of juncenolide K (1) was determined by single-crystal X-ray diffraction analysis for the first time in this study and the structure, including the absolute configuration of briarane 2 was established on the basis of spectroscopic analysis and compared with that of model compound 1. One aspect of the stereochemistry of the known compound 1 was revised. Briarane 2 was found to enhance the generation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7 cells.

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