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Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma
Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the sign...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231247/ https://www.ncbi.nlm.nih.gov/pubmed/32340364 http://dx.doi.org/10.3390/jcm9041218 |
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author | Yeh, Hsin-Chih Li, Ching-Chia Wen, Sheng-Chen Singla, Nirmish Woldu, Solomon L. Robyak, Haley Huang, Chun-Nung Ke, Hung-Lung Li, Wei-Ming Lee, Hsiang-Ying Li, Chia-Yang Yeh, Bi-Wen Yang, Sheau-Fang Tu, Hung-Pin Shariat, Shahrokh F. Sagalowsky, Arthur I. Raman, Jay D. Lotan, Yair Hsieh, Jer-Tsong Margulis, Vitaly Wu, Wen-Jeng |
author_facet | Yeh, Hsin-Chih Li, Ching-Chia Wen, Sheng-Chen Singla, Nirmish Woldu, Solomon L. Robyak, Haley Huang, Chun-Nung Ke, Hung-Lung Li, Wei-Ming Lee, Hsiang-Ying Li, Chia-Yang Yeh, Bi-Wen Yang, Sheau-Fang Tu, Hung-Pin Shariat, Shahrokh F. Sagalowsky, Arthur I. Raman, Jay D. Lotan, Yair Hsieh, Jer-Tsong Margulis, Vitaly Wu, Wen-Jeng |
author_sort | Yeh, Hsin-Chih |
collection | PubMed |
description | Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic characteristics were compared according to the presence of hyponatremia. Univariate and multivariate Cox regression models were used to investigate the association of hyponatremia with disease progression and survival. The impact of hyponatremia in patients from distinct regions was also analyzed. Hyponatremia was found in 143 (19.4%) patients. Hyponatremic patients had significantly worse Eastern Cooperative Oncology Group (ECOG) performance status (p = 0.00001) and higher pT stage (p = 0.002). In multivariate analysis, hyponatremia was an independent prognostic factor for progression (HR 1.585, 95% CI 1.115–2.253, p = 0.010), cancer-specific death (HR 2.225, 95% CI 1.457–3.397, p = 0.0002), and overall mortality (HR 1.819, 95% CI 1.299–2.545, p = 0.0005). Kaplan–Meier analysis showed the consistent adverse effect of hyponatremia on all outcomes in patients from Taiwan and the U.S. (all p < 0.05). Hyponatremia is commonly accessible and can serve as a negative marker for both the general health condition and disease severity of UTUC patients. A similar implication of hyponatremia in progression and survival despite patients’ region of presentation suggests its general applicability across different ethnicities. |
format | Online Article Text |
id | pubmed-7231247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72312472020-05-22 Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma Yeh, Hsin-Chih Li, Ching-Chia Wen, Sheng-Chen Singla, Nirmish Woldu, Solomon L. Robyak, Haley Huang, Chun-Nung Ke, Hung-Lung Li, Wei-Ming Lee, Hsiang-Ying Li, Chia-Yang Yeh, Bi-Wen Yang, Sheau-Fang Tu, Hung-Pin Shariat, Shahrokh F. Sagalowsky, Arthur I. Raman, Jay D. Lotan, Yair Hsieh, Jer-Tsong Margulis, Vitaly Wu, Wen-Jeng J Clin Med Article Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic characteristics were compared according to the presence of hyponatremia. Univariate and multivariate Cox regression models were used to investigate the association of hyponatremia with disease progression and survival. The impact of hyponatremia in patients from distinct regions was also analyzed. Hyponatremia was found in 143 (19.4%) patients. Hyponatremic patients had significantly worse Eastern Cooperative Oncology Group (ECOG) performance status (p = 0.00001) and higher pT stage (p = 0.002). In multivariate analysis, hyponatremia was an independent prognostic factor for progression (HR 1.585, 95% CI 1.115–2.253, p = 0.010), cancer-specific death (HR 2.225, 95% CI 1.457–3.397, p = 0.0002), and overall mortality (HR 1.819, 95% CI 1.299–2.545, p = 0.0005). Kaplan–Meier analysis showed the consistent adverse effect of hyponatremia on all outcomes in patients from Taiwan and the U.S. (all p < 0.05). Hyponatremia is commonly accessible and can serve as a negative marker for both the general health condition and disease severity of UTUC patients. A similar implication of hyponatremia in progression and survival despite patients’ region of presentation suggests its general applicability across different ethnicities. MDPI 2020-04-23 /pmc/articles/PMC7231247/ /pubmed/32340364 http://dx.doi.org/10.3390/jcm9041218 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yeh, Hsin-Chih Li, Ching-Chia Wen, Sheng-Chen Singla, Nirmish Woldu, Solomon L. Robyak, Haley Huang, Chun-Nung Ke, Hung-Lung Li, Wei-Ming Lee, Hsiang-Ying Li, Chia-Yang Yeh, Bi-Wen Yang, Sheau-Fang Tu, Hung-Pin Shariat, Shahrokh F. Sagalowsky, Arthur I. Raman, Jay D. Lotan, Yair Hsieh, Jer-Tsong Margulis, Vitaly Wu, Wen-Jeng Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title | Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title_full | Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title_fullStr | Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title_full_unstemmed | Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title_short | Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma |
title_sort | validation of hyponatremia as a prognostic predictor in multiregional upper tract urothelial carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231247/ https://www.ncbi.nlm.nih.gov/pubmed/32340364 http://dx.doi.org/10.3390/jcm9041218 |
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