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Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases

Metastases to orofacial tissues are infrequent, their incidence being 1%–8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gin...

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Autores principales: Capodiferro, Saverio, Limongelli, Luisa, Mastropasqua, Mauro Giuseppe, Favia, Gianfranco, Lajolo, Carlo, Colella, Giuseppe, Tempesta, Angela, Maiorano, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231269/
https://www.ncbi.nlm.nih.gov/pubmed/32316524
http://dx.doi.org/10.3390/jcm9041151
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author Capodiferro, Saverio
Limongelli, Luisa
Mastropasqua, Mauro Giuseppe
Favia, Gianfranco
Lajolo, Carlo
Colella, Giuseppe
Tempesta, Angela
Maiorano, Eugenio
author_facet Capodiferro, Saverio
Limongelli, Luisa
Mastropasqua, Mauro Giuseppe
Favia, Gianfranco
Lajolo, Carlo
Colella, Giuseppe
Tempesta, Angela
Maiorano, Eugenio
author_sort Capodiferro, Saverio
collection PubMed
description Metastases to orofacial tissues are infrequent, their incidence being 1%–8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. In view of the necessity for prompt and accurate diagnosis of such unusual neoplasms, we report on the salient clinico-pathological features of 7 CCRCC metastatic to the oro-facial tissues, and highlight their immunohistochemical profile, to more accurately discriminate this neoplasm from other tumors of the oral cavity with a prominent clear cell component.
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spelling pubmed-72312692020-05-22 Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases Capodiferro, Saverio Limongelli, Luisa Mastropasqua, Mauro Giuseppe Favia, Gianfranco Lajolo, Carlo Colella, Giuseppe Tempesta, Angela Maiorano, Eugenio J Clin Med Article Metastases to orofacial tissues are infrequent, their incidence being 1%–8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. In view of the necessity for prompt and accurate diagnosis of such unusual neoplasms, we report on the salient clinico-pathological features of 7 CCRCC metastatic to the oro-facial tissues, and highlight their immunohistochemical profile, to more accurately discriminate this neoplasm from other tumors of the oral cavity with a prominent clear cell component. MDPI 2020-04-17 /pmc/articles/PMC7231269/ /pubmed/32316524 http://dx.doi.org/10.3390/jcm9041151 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capodiferro, Saverio
Limongelli, Luisa
Mastropasqua, Mauro Giuseppe
Favia, Gianfranco
Lajolo, Carlo
Colella, Giuseppe
Tempesta, Angela
Maiorano, Eugenio
Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title_full Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title_fullStr Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title_full_unstemmed Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title_short Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases
title_sort metastatic tumors of the oro-facial tissues: clear cell renal cell carcinoma. a clinico-pathological and immunohistochemical study of seven cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231269/
https://www.ncbi.nlm.nih.gov/pubmed/32316524
http://dx.doi.org/10.3390/jcm9041151
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