Cargando…

Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial

In this randomized, double-blind, single-center trial (ANZCTR number ACTRN12619000436178) we aimed to investigate changes in endothelium-dependent vasodilation induced by ubiquinol, the reduced form of coenzyme Q10 (CoQ10), in healthy subjects with moderate dyslipidemia. Fifty-one subjects with low-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sabbatinelli, Jacopo, Orlando, Patrick, Galeazzi, Roberta, Silvestri, Sonia, Cirilli, Ilenia, Marcheggiani, Fabio, Dludla, Phiwayinkosi V., Giuliani, Angelica, Bonfigli, Anna Rita, Mazzanti, Laura, Olivieri, Fabiola, Antonicelli, Roberto, Tiano, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231284/ https://www.ncbi.nlm.nih.gov/pubmed/32326664 http://dx.doi.org/10.3390/nu12041098

Ejemplares similares

Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
por: Orlando, Patrick, et al.
Publicado: (2020)

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes
por: Orlando, Patrick, et al.
Publicado: (2018)

The Protective Role of Bioactive Quinones in Stress-induced Senescence Phenotype of Endothelial Cells Exposed to Cigarette Smoke Extract
por: Cirilli, Ilenia, et al.
Publicado: (2020)

Carboxylative efficacy of trans and cis MK7 and comparison with other vitamin K isomers
por: Cirilli, Ilenia, et al.
Publicado: (2022)

Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
por: Cirilli, Ilenia, et al.
Publicado: (2019)

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents
por: Giuliani, Angelica, et al.
Publicado: (2022)

Role of Coenzyme Q(10) in Health and Disease: An Update on the Last 10 Years (2010–2020)
por: Cirilli, Ilenia, et al.
Publicado: (2021)

Bioavailability Study of Isothiocyanates and Other Bioactive Compounds of Brassica oleracea L. var. Italica Boiled or Steamed: Functional Food or Dietary Supplement?
por: Orlando, Patrick, et al.
Publicado: (2022)

Modulation of Oxidative Status by Normoxia and Hypoxia on Cultures of Human Dermal Fibroblasts: How Does It Affect Cell Aging?
por: Damiani, Elisabetta, et al.
Publicado: (2018)

N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q(9/10) levels
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2019)

Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile
por: Orlando, Patrick, et al.
Publicado: (2019)

Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
por: Protic, Olga, et al.
Publicado: (2022)

The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
por: Giuliani, Angelica, et al.
Publicado: (2018)

Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys
por: Orlando, Patrick, et al.
Publicado: (2019)

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity
por: Giannubilo, Stefano Raffaele, et al.
Publicado: (2018)

Coenzyme Q(10) Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease
por: Spazzafumo, Liana, et al.
Publicado: (2021)

CoQ(10)Phytosomes Improve Cellular Ubiquinone Uptake in Skeletal Muscle Cells: An Ex Vivo Study Using CoQ(10)-Enriched Low-Density Lipoproteins Obtained in a Randomized Crossover Study
por: Marcheggiani, Fabio, et al.
Publicado: (2023)

Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2023)

Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2023)

The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-O-β-d-glucoside from Rooibos against Hyperglycemia-Induced Cardiac Damage: An In Vitro Study
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Modulation of Coenzyme Q(10) content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging
por: Marcheggiani, Fabio, et al.
Publicado: (2019)

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices
por: Perugini, Jessica, et al.
Publicado: (2022)

Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients
por: Olivieri, Fabiola, et al.
Publicado: (2022)

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
por: Bonafè, Massimiliano, et al.
Publicado: (2020)

Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2020)

Circulating PCSK9 as a prognostic biomarker of cardiovascular events in individuals with type 2 diabetes: evidence from a 16.8-year follow-up study
por: Ruscica, Massimiliano, et al.
Publicado: (2023)

Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in hospitalized geriatric patients independent of the admission diagnosis: a multicenter prospective cohort study
por: Di Rosa, Mirko, et al.
Publicado: (2023)

Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev” by Eugenia Quiros-Roldan, Giorgio Biasiotto and Isabella Zanella
por: Prattichizzo, Francesco, et al.
Publicado: (2021)

Where Metabolism Meets Senescence: Focus on Endothelial Cells
por: Sabbatinelli, Jacopo, et al.
Publicado: (2019)

Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

Circulating Inflamma-miRs as Potential Biomarkers of Cognitive Impairment in Patients Affected by Alzheimer’s Disease
por: Giuliani, Angelica, et al.
Publicado: (2021)

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging
por: Conte, Maria, et al.
Publicado: (2020)

Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2018)

Effects of a novel nutraceutical combination (BruMeChol™) in subjects with mild hypercholesterolemia: study protocol of a randomized, double-blind, controlled trial
por: Bonfigli, Anna Rita, et al.
Publicado: (2020)

Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications
por: Prattichizzo, Francesco, et al.
Publicado: (2021)

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

Effect of Sphingomyelinase-Treated LDLs on HUVECs
por: Giuliani, Angelica, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7bnugkhl7no4unv8c4u6d4smvs