Comparison and Combination of Organic Solvent Nanofiltration and Adsorption Processes: A Mathematical Approach for Mitigation of Active Pharmaceutical Ingredient Losses during Genotoxin Removal

Active pharmaceutical ingredients (API) are synthesized using highly reactive reagents, catalysts, and solvents. Some of those persist as impurities in the final product and are genotoxic or carcinogenic. The conventional processes used for API purification and isolation are able to achieve the limi...

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Detalles Bibliográficos
Autores principales: Ferreira, Flávio, Resina, Leonor, Esteves, Teresa, Ferreira, Frederico Castelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231377/
https://www.ncbi.nlm.nih.gov/pubmed/32316155
http://dx.doi.org/10.3390/membranes10040073

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