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Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy

Neovascular retinal degenerative diseases are the leading causes of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) therapy is commonly used to treat these diseases currently. However, recent reports indicate that long term suppression of VEGF in the eye is associate...

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Autores principales: Shoda, Chiho, Miwa, Yukihiro, Nimura, Kazumi, Okamoto, Kazutoshi, Yamagami, Satoru, Tsubota, Kazuo, Kurihara, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231390/
https://www.ncbi.nlm.nih.gov/pubmed/32290307
http://dx.doi.org/10.3390/nu12041055
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author Shoda, Chiho
Miwa, Yukihiro
Nimura, Kazumi
Okamoto, Kazutoshi
Yamagami, Satoru
Tsubota, Kazuo
Kurihara, Toshihide
author_facet Shoda, Chiho
Miwa, Yukihiro
Nimura, Kazumi
Okamoto, Kazutoshi
Yamagami, Satoru
Tsubota, Kazuo
Kurihara, Toshihide
author_sort Shoda, Chiho
collection PubMed
description Neovascular retinal degenerative diseases are the leading causes of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) therapy is commonly used to treat these diseases currently. However, recent reports indicate that long term suppression of VEGF in the eye is associated with chorioretinal atrophy. Therefore, a physiological amount of VEGF is required for retinal homeostasis. Hypoxia-inducible factor (HIF) is a transcriptional factor upstream of VEGF. We previously reported that HIF regulated pathological angiogenesis in the retina of murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization. Most of the known HIF inhibitors are anti-cancer agents which may have systemic adverse effects in for clinical use; thus, there is a need for safer and less invasive HIF inhibitors. In this study, we screened marine products, especially fish ingredients, and found that six species of fish had HIF inhibitory effects. Among them, administration of Decapterus tabl ingredients significantly suppressed retinal neovascular tufts by inhibiting HIF expression in a murine oxygen-induced retinopathy model. These results indicate that particular fish ingredients can act as anti-angiogenic agents in retinal neovascularization diseases.
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spelling pubmed-72313902020-05-22 Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy Shoda, Chiho Miwa, Yukihiro Nimura, Kazumi Okamoto, Kazutoshi Yamagami, Satoru Tsubota, Kazuo Kurihara, Toshihide Nutrients Article Neovascular retinal degenerative diseases are the leading causes of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) therapy is commonly used to treat these diseases currently. However, recent reports indicate that long term suppression of VEGF in the eye is associated with chorioretinal atrophy. Therefore, a physiological amount of VEGF is required for retinal homeostasis. Hypoxia-inducible factor (HIF) is a transcriptional factor upstream of VEGF. We previously reported that HIF regulated pathological angiogenesis in the retina of murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization. Most of the known HIF inhibitors are anti-cancer agents which may have systemic adverse effects in for clinical use; thus, there is a need for safer and less invasive HIF inhibitors. In this study, we screened marine products, especially fish ingredients, and found that six species of fish had HIF inhibitory effects. Among them, administration of Decapterus tabl ingredients significantly suppressed retinal neovascular tufts by inhibiting HIF expression in a murine oxygen-induced retinopathy model. These results indicate that particular fish ingredients can act as anti-angiogenic agents in retinal neovascularization diseases. MDPI 2020-04-10 /pmc/articles/PMC7231390/ /pubmed/32290307 http://dx.doi.org/10.3390/nu12041055 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shoda, Chiho
Miwa, Yukihiro
Nimura, Kazumi
Okamoto, Kazutoshi
Yamagami, Satoru
Tsubota, Kazuo
Kurihara, Toshihide
Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title_full Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title_fullStr Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title_full_unstemmed Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title_short Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy
title_sort hypoxia-inducible factor inhibitors derived from marine products suppress a murine model of neovascular retinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231390/
https://www.ncbi.nlm.nih.gov/pubmed/32290307
http://dx.doi.org/10.3390/nu12041055
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