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The pathological role of ferroptosis in ischemia/reperfusion-related injury

Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid pe...

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Autores principales: Yan, Hong-Fa, Tuo, Qing-Zhang, Yin, Qiao-Zhi, Lei, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231469/
https://www.ncbi.nlm.nih.gov/pubmed/32314558
http://dx.doi.org/10.24272/j.issn.2095-8137.2020.042
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author Yan, Hong-Fa
Tuo, Qing-Zhang
Yin, Qiao-Zhi
Lei, Peng
author_facet Yan, Hong-Fa
Tuo, Qing-Zhang
Yin, Qiao-Zhi
Lei, Peng
author_sort Yan, Hong-Fa
collection PubMed
description Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.
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spelling pubmed-72314692020-05-18 The pathological role of ferroptosis in ischemia/reperfusion-related injury Yan, Hong-Fa Tuo, Qing-Zhang Yin, Qiao-Zhi Lei, Peng Zool Res Reviews Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death. Science Press 2020-05-18 /pmc/articles/PMC7231469/ /pubmed/32314558 http://dx.doi.org/10.24272/j.issn.2095-8137.2020.042 Text en Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Yan, Hong-Fa
Tuo, Qing-Zhang
Yin, Qiao-Zhi
Lei, Peng
The pathological role of ferroptosis in ischemia/reperfusion-related injury
title The pathological role of ferroptosis in ischemia/reperfusion-related injury
title_full The pathological role of ferroptosis in ischemia/reperfusion-related injury
title_fullStr The pathological role of ferroptosis in ischemia/reperfusion-related injury
title_full_unstemmed The pathological role of ferroptosis in ischemia/reperfusion-related injury
title_short The pathological role of ferroptosis in ischemia/reperfusion-related injury
title_sort pathological role of ferroptosis in ischemia/reperfusion-related injury
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231469/
https://www.ncbi.nlm.nih.gov/pubmed/32314558
http://dx.doi.org/10.24272/j.issn.2095-8137.2020.042
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