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Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study

OBJECTIVES: To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan. METHODS: In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, tre...

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Autores principales: Qi, Lin, Yang, Yong, Jiang, Dixuan, Tu, Chao, Wan, Lu, Chen, Xiangyu, Li, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231495/
https://www.ncbi.nlm.nih.gov/pubmed/32425636
http://dx.doi.org/10.1016/j.ijid.2020.05.045
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author Qi, Lin
Yang, Yong
Jiang, Dixuan
Tu, Chao
Wan, Lu
Chen, Xiangyu
Li, Zhihong
author_facet Qi, Lin
Yang, Yong
Jiang, Dixuan
Tu, Chao
Wan, Lu
Chen, Xiangyu
Li, Zhihong
author_sort Qi, Lin
collection PubMed
description OBJECTIVES: To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan. METHODS: In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors. RESULTS: Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12–21). Multivariate Logistic regression analysis indicated that the highest temperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI]: 1.190−22.726; p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI: 1.296−2.337; p < 0.001) and hospital length of stay (OR, 1.604; 95% CI: 1.262−2.040; p < 0.001) were risk factors for prolonged duration of viral shedding. CONCLUSIONS: This study, with a relatively large sample size, focused on the duration of viral shedding and related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified and should be taken into consideration for the strategy of quarantining infected patients.
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spelling pubmed-72314952020-05-18 Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study Qi, Lin Yang, Yong Jiang, Dixuan Tu, Chao Wan, Lu Chen, Xiangyu Li, Zhihong Int J Infect Dis Article OBJECTIVES: To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan. METHODS: In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors. RESULTS: Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12–21). Multivariate Logistic regression analysis indicated that the highest temperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI]: 1.190−22.726; p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI: 1.296−2.337; p < 0.001) and hospital length of stay (OR, 1.604; 95% CI: 1.262−2.040; p < 0.001) were risk factors for prolonged duration of viral shedding. CONCLUSIONS: This study, with a relatively large sample size, focused on the duration of viral shedding and related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified and should be taken into consideration for the strategy of quarantining infected patients. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-07 2020-05-17 /pmc/articles/PMC7231495/ /pubmed/32425636 http://dx.doi.org/10.1016/j.ijid.2020.05.045 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Qi, Lin
Yang, Yong
Jiang, Dixuan
Tu, Chao
Wan, Lu
Chen, Xiangyu
Li, Zhihong
Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title_full Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title_fullStr Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title_full_unstemmed Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title_short Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
title_sort factors associated with the duration of viral shedding in adults with covid-19 outside of wuhan, china: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231495/
https://www.ncbi.nlm.nih.gov/pubmed/32425636
http://dx.doi.org/10.1016/j.ijid.2020.05.045
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