Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding...

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Detalles Bibliográficos
Autores principales: Cao, Yunlong, Su, Bin, Guo, Xianghua, Sun, Wenjie, Deng, Yongqiang, Bao, Linlin, Zhu, Qinyu, Zhang, Xu, Zheng, Yinghui, Geng, Chenyang, Chai, Xiaoran, He, Runsheng, Li, Xiaofeng, Lv, Qi, Zhu, Hua, Deng, Wei, Xu, Yanfeng, Wang, Yanjun, Qiao, Luxin, Tan, Yafang, Song, Liyang, Wang, Guopeng, Du, Xiaoxia, Gao, Ning, Liu, Jiangning, Xiao, Junyu, Su, Xiao-dong, Du, Zongmin, Feng, Yingmei, Qin, Chuan, Qin, Chengfeng, Jin, Ronghua, Xie, X. Sunney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231725/
https://www.ncbi.nlm.nih.gov/pubmed/32425270
http://dx.doi.org/10.1016/j.cell.2020.05.025

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