Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblasti...

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Detalles Bibliográficos
Autores principales: Russo, Flávia Tobaldini, Macedo, Maria Cristina Martins de Almeida, Fernades, Pedro Amoedo, Okada, Larissa Yukari, da Silva, Lucas Augusto Monetta, Simões, Camila Menin, Cavalcante, Jamilla Neves, Simões, Aline de Almeida, Almeida, Manuella de Souza Sampaio, Lopes, Maricy Almeida Viol Ferreira, da Silva, Roberto Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231792/
https://www.ncbi.nlm.nih.gov/pubmed/32461796
Descripción
Sumario:Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.

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