Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblasti...

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Autores principales: Russo, Flávia Tobaldini, Macedo, Maria Cristina Martins de Almeida, Fernades, Pedro Amoedo, Okada, Larissa Yukari, da Silva, Lucas Augusto Monetta, Simões, Camila Menin, Cavalcante, Jamilla Neves, Simões, Aline de Almeida, Almeida, Manuella de Souza Sampaio, Lopes, Maricy Almeida Viol Ferreira, da Silva, Roberto Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231792/
https://www.ncbi.nlm.nih.gov/pubmed/32461796
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author Russo, Flávia Tobaldini
Macedo, Maria Cristina Martins de Almeida
Fernades, Pedro Amoedo
Okada, Larissa Yukari
da Silva, Lucas Augusto Monetta
Simões, Camila Menin
Cavalcante, Jamilla Neves
Simões, Aline de Almeida
Almeida, Manuella de Souza Sampaio
Lopes, Maricy Almeida Viol Ferreira
da Silva, Roberto Luiz
author_facet Russo, Flávia Tobaldini
Macedo, Maria Cristina Martins de Almeida
Fernades, Pedro Amoedo
Okada, Larissa Yukari
da Silva, Lucas Augusto Monetta
Simões, Camila Menin
Cavalcante, Jamilla Neves
Simões, Aline de Almeida
Almeida, Manuella de Souza Sampaio
Lopes, Maricy Almeida Viol Ferreira
da Silva, Roberto Luiz
author_sort Russo, Flávia Tobaldini
collection PubMed
description Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.
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spelling pubmed-72317922020-05-26 Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols Russo, Flávia Tobaldini Macedo, Maria Cristina Martins de Almeida Fernades, Pedro Amoedo Okada, Larissa Yukari da Silva, Lucas Augusto Monetta Simões, Camila Menin Cavalcante, Jamilla Neves Simões, Aline de Almeida Almeida, Manuella de Souza Sampaio Lopes, Maricy Almeida Viol Ferreira da Silva, Roberto Luiz Int J Hematol Oncol Stem Cell Res Case Report Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2020-04-01 /pmc/articles/PMC7231792/ /pubmed/32461796 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Russo, Flávia Tobaldini
Macedo, Maria Cristina Martins de Almeida
Fernades, Pedro Amoedo
Okada, Larissa Yukari
da Silva, Lucas Augusto Monetta
Simões, Camila Menin
Cavalcante, Jamilla Neves
Simões, Aline de Almeida
Almeida, Manuella de Souza Sampaio
Lopes, Maricy Almeida Viol Ferreira
da Silva, Roberto Luiz
Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title_full Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title_fullStr Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title_full_unstemmed Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title_short Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
title_sort treatment of acute lymphoid leukemia refractory to classic first-line and rescue protocols
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231792/
https://www.ncbi.nlm.nih.gov/pubmed/32461796
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