Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis

The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study,...

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Detalles Bibliográficos
Autores principales: Xiao, Qi, Hu, Yuhong, Yang, Xiaohong, Tang, Jianna, Wang, Xiaoshuang, Xue, Xiaomin, Li, Mengxue, Wang, Minjing, Zhao, Yinan, Liu, Jingze, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231830/
https://www.ncbi.nlm.nih.gov/pubmed/32418385
http://dx.doi.org/10.3347/kjp.2020.58.2.161
Descripción
Sumario:The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.

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