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Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis

The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study,...

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Autores principales: Xiao, Qi, Hu, Yuhong, Yang, Xiaohong, Tang, Jianna, Wang, Xiaoshuang, Xue, Xiaomin, Li, Mengxue, Wang, Minjing, Zhao, Yinan, Liu, Jingze, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231830/
https://www.ncbi.nlm.nih.gov/pubmed/32418385
http://dx.doi.org/10.3347/kjp.2020.58.2.161
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author Xiao, Qi
Hu, Yuhong
Yang, Xiaohong
Tang, Jianna
Wang, Xiaoshuang
Xue, Xiaomin
Li, Mengxue
Wang, Minjing
Zhao, Yinan
Liu, Jingze
Wang, Hui
author_facet Xiao, Qi
Hu, Yuhong
Yang, Xiaohong
Tang, Jianna
Wang, Xiaoshuang
Xue, Xiaomin
Li, Mengxue
Wang, Minjing
Zhao, Yinan
Liu, Jingze
Wang, Hui
author_sort Xiao, Qi
collection PubMed
description The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.
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spelling pubmed-72318302020-05-29 Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis Xiao, Qi Hu, Yuhong Yang, Xiaohong Tang, Jianna Wang, Xiaoshuang Xue, Xiaomin Li, Mengxue Wang, Minjing Zhao, Yinan Liu, Jingze Wang, Hui Korean J Parasitol Original Article The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration. The Korean Society for Parasitology and Tropical Medicine 2020-04 2020-04-30 /pmc/articles/PMC7231830/ /pubmed/32418385 http://dx.doi.org/10.3347/kjp.2020.58.2.161 Text en Copyright © 2020 by The Korean Society for Parasitology and Tropical Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Xiao, Qi
Hu, Yuhong
Yang, Xiaohong
Tang, Jianna
Wang, Xiaoshuang
Xue, Xiaomin
Li, Mengxue
Wang, Minjing
Zhao, Yinan
Liu, Jingze
Wang, Hui
Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title_full Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title_fullStr Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title_full_unstemmed Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title_short Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
title_sort changes in protein phosphorylation during salivary gland degeneration in haemaphysalis longicornis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231830/
https://www.ncbi.nlm.nih.gov/pubmed/32418385
http://dx.doi.org/10.3347/kjp.2020.58.2.161
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