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Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Parasitology and Tropical Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231830/ https://www.ncbi.nlm.nih.gov/pubmed/32418385 http://dx.doi.org/10.3347/kjp.2020.58.2.161 |
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author | Xiao, Qi Hu, Yuhong Yang, Xiaohong Tang, Jianna Wang, Xiaoshuang Xue, Xiaomin Li, Mengxue Wang, Minjing Zhao, Yinan Liu, Jingze Wang, Hui |
author_facet | Xiao, Qi Hu, Yuhong Yang, Xiaohong Tang, Jianna Wang, Xiaoshuang Xue, Xiaomin Li, Mengxue Wang, Minjing Zhao, Yinan Liu, Jingze Wang, Hui |
author_sort | Xiao, Qi |
collection | PubMed |
description | The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration. |
format | Online Article Text |
id | pubmed-7231830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Society for Parasitology and Tropical Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-72318302020-05-29 Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis Xiao, Qi Hu, Yuhong Yang, Xiaohong Tang, Jianna Wang, Xiaoshuang Xue, Xiaomin Li, Mengxue Wang, Minjing Zhao, Yinan Liu, Jingze Wang, Hui Korean J Parasitol Original Article The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration. The Korean Society for Parasitology and Tropical Medicine 2020-04 2020-04-30 /pmc/articles/PMC7231830/ /pubmed/32418385 http://dx.doi.org/10.3347/kjp.2020.58.2.161 Text en Copyright © 2020 by The Korean Society for Parasitology and Tropical Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Xiao, Qi Hu, Yuhong Yang, Xiaohong Tang, Jianna Wang, Xiaoshuang Xue, Xiaomin Li, Mengxue Wang, Minjing Zhao, Yinan Liu, Jingze Wang, Hui Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title | Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title_full | Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title_fullStr | Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title_full_unstemmed | Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title_short | Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis |
title_sort | changes in protein phosphorylation during salivary gland degeneration in haemaphysalis longicornis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231830/ https://www.ncbi.nlm.nih.gov/pubmed/32418385 http://dx.doi.org/10.3347/kjp.2020.58.2.161 |
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