Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?

SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine...

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Detalles Bibliográficos
Autores principales: Abeygunasekera, Anuruddha, Jayasinghe, Saroj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232076/
https://www.ncbi.nlm.nih.gov/pubmed/32492560
http://dx.doi.org/10.1016/j.mehy.2020.109843
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author Abeygunasekera, Anuruddha
Jayasinghe, Saroj
author_facet Abeygunasekera, Anuruddha
Jayasinghe, Saroj
author_sort Abeygunasekera, Anuruddha
collection PubMed
description SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.
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spelling pubmed-72320762020-05-18 Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? Abeygunasekera, Anuruddha Jayasinghe, Saroj Med Hypotheses Article SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19. Elsevier Ltd. 2020-10 2020-05-18 /pmc/articles/PMC7232076/ /pubmed/32492560 http://dx.doi.org/10.1016/j.mehy.2020.109843 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Abeygunasekera, Anuruddha
Jayasinghe, Saroj
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title_full Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title_fullStr Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title_full_unstemmed Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title_short Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
title_sort is the anti-filarial drug diethylcarbamazine useful to treat covid-19?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232076/
https://www.ncbi.nlm.nih.gov/pubmed/32492560
http://dx.doi.org/10.1016/j.mehy.2020.109843
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