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Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems

The development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as ca...

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Autores principales: Souza, Maurício Palmeira Chaves de, Sábio, Rafael Miguel, Ribeiro, Tais de Cassia, Santos, Aline Martins dos, Meneguin, Andréia Bagliotti, Chorilli, Marlus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232078/
https://www.ncbi.nlm.nih.gov/pubmed/32425271
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.104
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author Souza, Maurício Palmeira Chaves de
Sábio, Rafael Miguel
Ribeiro, Tais de Cassia
Santos, Aline Martins dos
Meneguin, Andréia Bagliotti
Chorilli, Marlus
author_facet Souza, Maurício Palmeira Chaves de
Sábio, Rafael Miguel
Ribeiro, Tais de Cassia
Santos, Aline Martins dos
Meneguin, Andréia Bagliotti
Chorilli, Marlus
author_sort Souza, Maurício Palmeira Chaves de
collection PubMed
description The development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as cationic nature, biodegradability, biocompatibility and important mucoadhesiveness, which make CS a promising biopolymer to design effective gastroretentive systems. In light of this, we reported in this review the CS versatility to fabricate different types of nano- and microstructured gastroretentive systems. For a better understanding of the gastric retention mechanisms, we highlighted expandable, density-based, magnetic, mucoadhesive and superporous systems. The biological and chemical properties of CS, anatomophysiological aspects related to gastrointestinal tract (GIT) and some applications of these systems are also described here. Overall, this review may assist researchers to explore new strategies to design safe and efficient gastroretentive systems in order to popularize them in the treatment of diseases and clinical practices.
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spelling pubmed-72320782020-05-18 Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems Souza, Maurício Palmeira Chaves de Sábio, Rafael Miguel Ribeiro, Tais de Cassia Santos, Aline Martins dos Meneguin, Andréia Bagliotti Chorilli, Marlus Int J Biol Macromol Article The development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as cationic nature, biodegradability, biocompatibility and important mucoadhesiveness, which make CS a promising biopolymer to design effective gastroretentive systems. In light of this, we reported in this review the CS versatility to fabricate different types of nano- and microstructured gastroretentive systems. For a better understanding of the gastric retention mechanisms, we highlighted expandable, density-based, magnetic, mucoadhesive and superporous systems. The biological and chemical properties of CS, anatomophysiological aspects related to gastrointestinal tract (GIT) and some applications of these systems are also described here. Overall, this review may assist researchers to explore new strategies to design safe and efficient gastroretentive systems in order to popularize them in the treatment of diseases and clinical practices. Published by Elsevier B.V. 2020-09-15 2020-05-18 /pmc/articles/PMC7232078/ /pubmed/32425271 http://dx.doi.org/10.1016/j.ijbiomac.2020.05.104 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Souza, Maurício Palmeira Chaves de
Sábio, Rafael Miguel
Ribeiro, Tais de Cassia
Santos, Aline Martins dos
Meneguin, Andréia Bagliotti
Chorilli, Marlus
Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title_full Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title_fullStr Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title_full_unstemmed Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title_short Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
title_sort highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232078/
https://www.ncbi.nlm.nih.gov/pubmed/32425271
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.104
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