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Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix

Targeted stimulation of white matter has opened newer perspectives in the field of neuromodulation, towards an attempt to improve memory or as a therapy for epilepsy. Stimulation of the fornix, being a part of the Papez circuit, is likely to modulate the limbic network excitability. However, the sti...

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Autores principales: Chaitanya, Ganne, Toth, Emilia, Pizarro, Diana, Iasemidis, Leonidas, Murray, Teresa A., Riley, Kristen, Pati, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232081/
https://www.ncbi.nlm.nih.gov/pubmed/32435756
http://dx.doi.org/10.1016/j.ebr.2020.100363
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author Chaitanya, Ganne
Toth, Emilia
Pizarro, Diana
Iasemidis, Leonidas
Murray, Teresa A.
Riley, Kristen
Pati, Sandipan
author_facet Chaitanya, Ganne
Toth, Emilia
Pizarro, Diana
Iasemidis, Leonidas
Murray, Teresa A.
Riley, Kristen
Pati, Sandipan
author_sort Chaitanya, Ganne
collection PubMed
description Targeted stimulation of white matter has opened newer perspectives in the field of neuromodulation, towards an attempt to improve memory or as a therapy for epilepsy. Stimulation of the fornix, being a part of the Papez circuit, is likely to modulate the limbic network excitability. However, the stimulation-frequency dependent variability in network excitability is unknown. In the case study, which involved stereo electroencephalographic (SEEG) recording of field potentials in a 48-year old left-handed woman with suspected temporal lobe epilepsy, we demonstrated the network effects of acute low (1 and 10 Hz) and high (50 Hz) frequency electrical stimulation of fornix. Mapping the short-latency evoked responses to forniceal stimulation confirmed the SEEG target localization within the Papez circuit. Low and high-frequency stimulation of the fornix produced opposite effects in the post-stimuli excitability, with the latter causing increased excitability in the limbic network that culminated in a clinical seizure. A distinct spectral peak around 8 Hz confirmed that sensing field potentials from the forniceal white matter is feasible. This is the first case study that provided an insight into how the temporal patterning of forniceal stimulation altered the downstream limbic network excitability.
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spelling pubmed-72320812020-05-20 Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix Chaitanya, Ganne Toth, Emilia Pizarro, Diana Iasemidis, Leonidas Murray, Teresa A. Riley, Kristen Pati, Sandipan Epilepsy Behav Rep Article Targeted stimulation of white matter has opened newer perspectives in the field of neuromodulation, towards an attempt to improve memory or as a therapy for epilepsy. Stimulation of the fornix, being a part of the Papez circuit, is likely to modulate the limbic network excitability. However, the stimulation-frequency dependent variability in network excitability is unknown. In the case study, which involved stereo electroencephalographic (SEEG) recording of field potentials in a 48-year old left-handed woman with suspected temporal lobe epilepsy, we demonstrated the network effects of acute low (1 and 10 Hz) and high (50 Hz) frequency electrical stimulation of fornix. Mapping the short-latency evoked responses to forniceal stimulation confirmed the SEEG target localization within the Papez circuit. Low and high-frequency stimulation of the fornix produced opposite effects in the post-stimuli excitability, with the latter causing increased excitability in the limbic network that culminated in a clinical seizure. A distinct spectral peak around 8 Hz confirmed that sensing field potentials from the forniceal white matter is feasible. This is the first case study that provided an insight into how the temporal patterning of forniceal stimulation altered the downstream limbic network excitability. Elsevier 2020-04-23 /pmc/articles/PMC7232081/ /pubmed/32435756 http://dx.doi.org/10.1016/j.ebr.2020.100363 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chaitanya, Ganne
Toth, Emilia
Pizarro, Diana
Iasemidis, Leonidas
Murray, Teresa A.
Riley, Kristen
Pati, Sandipan
Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title_full Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title_fullStr Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title_full_unstemmed Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title_short Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
title_sort acute modulation of the limbic network with low and high-frequency stimulation of the human fornix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232081/
https://www.ncbi.nlm.nih.gov/pubmed/32435756
http://dx.doi.org/10.1016/j.ebr.2020.100363
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