Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins

Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 198...

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Detalles Bibliográficos
Autores principales: Hassell, Travis J.W., Charles, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232182/
https://www.ncbi.nlm.nih.gov/pubmed/32331272
http://dx.doi.org/10.3390/toxins12040269
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author Hassell, Travis J.W.
Charles, David
author_facet Hassell, Travis J.W.
Charles, David
author_sort Hassell, Travis J.W.
collection PubMed
description Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing.
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spelling pubmed-72321822020-05-22 Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins Hassell, Travis J.W. Charles, David Toxins (Basel) Review Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing. MDPI 2020-04-22 /pmc/articles/PMC7232182/ /pubmed/32331272 http://dx.doi.org/10.3390/toxins12040269 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hassell, Travis J.W.
Charles, David
Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title_full Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title_fullStr Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title_full_unstemmed Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title_short Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
title_sort treatment of blepharospasm and oromandibular dystonia with botulinum toxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232182/
https://www.ncbi.nlm.nih.gov/pubmed/32331272
http://dx.doi.org/10.3390/toxins12040269
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