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Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232262/ https://www.ncbi.nlm.nih.gov/pubmed/32344661 http://dx.doi.org/10.3390/microorganisms8040618 |
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author | Huang, Yuqing Kammenga, Jan E. |
author_facet | Huang, Yuqing Kammenga, Jan E. |
author_sort | Huang, Yuqing |
collection | PubMed |
description | The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions. |
format | Online Article Text |
id | pubmed-7232262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72322622020-05-22 Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota Huang, Yuqing Kammenga, Jan E. Microorganisms Review The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions. MDPI 2020-04-24 /pmc/articles/PMC7232262/ /pubmed/32344661 http://dx.doi.org/10.3390/microorganisms8040618 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Huang, Yuqing Kammenga, Jan E. Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title | Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title_full | Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title_fullStr | Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title_full_unstemmed | Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title_short | Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota |
title_sort | genetic variation in caenorhabditis elegans responses to pathogenic microbiota |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232262/ https://www.ncbi.nlm.nih.gov/pubmed/32344661 http://dx.doi.org/10.3390/microorganisms8040618 |
work_keys_str_mv | AT huangyuqing geneticvariationincaenorhabditiselegansresponsestopathogenicmicrobiota AT kammengajane geneticvariationincaenorhabditiselegansresponsestopathogenicmicrobiota |