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Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota

The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the...

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Autores principales: Huang, Yuqing, Kammenga, Jan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232262/
https://www.ncbi.nlm.nih.gov/pubmed/32344661
http://dx.doi.org/10.3390/microorganisms8040618
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author Huang, Yuqing
Kammenga, Jan E.
author_facet Huang, Yuqing
Kammenga, Jan E.
author_sort Huang, Yuqing
collection PubMed
description The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions.
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spelling pubmed-72322622020-05-22 Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota Huang, Yuqing Kammenga, Jan E. Microorganisms Review The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions. MDPI 2020-04-24 /pmc/articles/PMC7232262/ /pubmed/32344661 http://dx.doi.org/10.3390/microorganisms8040618 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Yuqing
Kammenga, Jan E.
Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title_full Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title_fullStr Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title_full_unstemmed Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title_short Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota
title_sort genetic variation in caenorhabditis elegans responses to pathogenic microbiota
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232262/
https://www.ncbi.nlm.nih.gov/pubmed/32344661
http://dx.doi.org/10.3390/microorganisms8040618
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