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Comparison of gE/gI- and TK/gE/gI-Gene-Deleted Pseudorabies Virus Vaccines Mediated by CRISPR/Cas9 and Cre/Lox Systems

Pseudorabies (PR), caused by pseudorabies virus (PRV), is an acute and febrile infectious disease in swine. To eradicate PR, a more efficacious vaccine needs to be developed. Here, the gE/gI- and TK/gE/gI-gene-deleted recombinant PRV (rGXΔgE/gI and rGXΔTK/gE/gI) are constructed through CRISPR/Cas9 a...

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Detalles Bibliográficos
Autores principales:	Li, Jianglong, Fang, Kui, Rong, Zhenxiang, Li, Xinxin, Ren, Xujiao, Ma, Hui, Chen, Huanchun, Li, Xiangmin, Qian, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232343/ https://www.ncbi.nlm.nih.gov/pubmed/32230737 http://dx.doi.org/10.3390/v12040369

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