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Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and acti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232439/ https://www.ncbi.nlm.nih.gov/pubmed/32235330 http://dx.doi.org/10.3390/v12040376 |
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author | Zhang, Yun Xu, Zhichao Cao, Yongchang |
author_facet | Zhang, Yun Xu, Zhichao Cao, Yongchang |
author_sort | Zhang, Yun |
collection | PubMed |
description | Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses. |
format | Online Article Text |
id | pubmed-7232439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72324392020-05-22 Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection Zhang, Yun Xu, Zhichao Cao, Yongchang Viruses Review Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses. MDPI 2020-03-29 /pmc/articles/PMC7232439/ /pubmed/32235330 http://dx.doi.org/10.3390/v12040376 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Yun Xu, Zhichao Cao, Yongchang Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title | Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title_full | Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title_fullStr | Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title_full_unstemmed | Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title_short | Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection |
title_sort | host–virus interaction: how host cells defend against influenza a virus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232439/ https://www.ncbi.nlm.nih.gov/pubmed/32235330 http://dx.doi.org/10.3390/v12040376 |
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