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Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection

Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and acti...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Xu, Zhichao, Cao, Yongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232439/
https://www.ncbi.nlm.nih.gov/pubmed/32235330
http://dx.doi.org/10.3390/v12040376
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author Zhang, Yun
Xu, Zhichao
Cao, Yongchang
author_facet Zhang, Yun
Xu, Zhichao
Cao, Yongchang
author_sort Zhang, Yun
collection PubMed
description Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses.
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spelling pubmed-72324392020-05-22 Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection Zhang, Yun Xu, Zhichao Cao, Yongchang Viruses Review Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses. MDPI 2020-03-29 /pmc/articles/PMC7232439/ /pubmed/32235330 http://dx.doi.org/10.3390/v12040376 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Yun
Xu, Zhichao
Cao, Yongchang
Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title_full Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title_fullStr Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title_full_unstemmed Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title_short Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
title_sort host–virus interaction: how host cells defend against influenza a virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232439/
https://www.ncbi.nlm.nih.gov/pubmed/32235330
http://dx.doi.org/10.3390/v12040376
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