Cargando…

Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes

Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Jingting, Yang, Lingyan, Zhang, Qibo, Meng, Jia, Lu, Zhi-Liang, Rong, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232448/
https://www.ncbi.nlm.nih.gov/pubmed/32244330
http://dx.doi.org/10.3390/v12040381
_version_ 1783535389673259008
author Zhu, Jingting
Yang, Lingyan
Zhang, Qibo
Meng, Jia
Lu, Zhi-Liang
Rong, Rong
author_facet Zhu, Jingting
Yang, Lingyan
Zhang, Qibo
Meng, Jia
Lu, Zhi-Liang
Rong, Rong
author_sort Zhu, Jingting
collection PubMed
description Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal simian acquired immunodeficiency syndrome (SAIDS), which can display disease features that are similar to acquired immunodeficiency syndrome in humans. In this study, we demonstrate that infection with SRV-8, a newly isolated subtype of SRV, triggered both autophagic and apoptotic pathways in Jurkat T lymphocytes. Following infection with SRV-8, the autophagic proteins LC3 and p62/SQSTM1 interacted with procaspase-8, which might be responsible for the activation of the caspase-8/-3 cascade and apoptosis in SRV-8-infected Jurkat cells. Our findings indicate that autophagic responses to SRV infection of T lymphocytes promote the apoptosis of T lymphocytes, which, in turn, might be a potential pathogenetic mechanism for the loss of T lymphocytes during SRV infection.
format Online
Article
Text
id pubmed-7232448
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72324482020-05-22 Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes Zhu, Jingting Yang, Lingyan Zhang, Qibo Meng, Jia Lu, Zhi-Liang Rong, Rong Viruses Article Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal simian acquired immunodeficiency syndrome (SAIDS), which can display disease features that are similar to acquired immunodeficiency syndrome in humans. In this study, we demonstrate that infection with SRV-8, a newly isolated subtype of SRV, triggered both autophagic and apoptotic pathways in Jurkat T lymphocytes. Following infection with SRV-8, the autophagic proteins LC3 and p62/SQSTM1 interacted with procaspase-8, which might be responsible for the activation of the caspase-8/-3 cascade and apoptosis in SRV-8-infected Jurkat cells. Our findings indicate that autophagic responses to SRV infection of T lymphocytes promote the apoptosis of T lymphocytes, which, in turn, might be a potential pathogenetic mechanism for the loss of T lymphocytes during SRV infection. MDPI 2020-03-31 /pmc/articles/PMC7232448/ /pubmed/32244330 http://dx.doi.org/10.3390/v12040381 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhu, Jingting
Yang, Lingyan
Zhang, Qibo
Meng, Jia
Lu, Zhi-Liang
Rong, Rong
Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title_full Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title_fullStr Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title_full_unstemmed Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title_short Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes
title_sort autophagy induced by simian retrovirus infection controls viral replication and apoptosis of jurkat t lymphocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232448/
https://www.ncbi.nlm.nih.gov/pubmed/32244330
http://dx.doi.org/10.3390/v12040381
work_keys_str_mv AT zhujingting autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes
AT yanglingyan autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes
AT zhangqibo autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes
AT mengjia autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes
AT luzhiliang autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes
AT rongrong autophagyinducedbysimianretrovirusinfectioncontrolsviralreplicationandapoptosisofjurkattlymphocytes