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Global Distribution and Evolution of Mycobacterium bovis Lineages

Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains based on limited DNA markers (a.k.a. clonal complexes), and the evolution and...

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Autores principales: Zimpel, Cristina Kraemer, Patané, José Salvatore L., Guedes, Aureliano Coelho Proença, de Souza, Robson F., Silva-Pereira, Taiana T., Camargo, Naila C. Soler, de Souza Filho, Antônio F., Ikuta, Cássia Y., Neto, José Soares Ferreira, Setubal, João Carlos, Heinemann, Marcos Bryan, Guimaraes, Ana Marcia Sa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232559/
https://www.ncbi.nlm.nih.gov/pubmed/32477295
http://dx.doi.org/10.3389/fmicb.2020.00843
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author Zimpel, Cristina Kraemer
Patané, José Salvatore L.
Guedes, Aureliano Coelho Proença
de Souza, Robson F.
Silva-Pereira, Taiana T.
Camargo, Naila C. Soler
de Souza Filho, Antônio F.
Ikuta, Cássia Y.
Neto, José Soares Ferreira
Setubal, João Carlos
Heinemann, Marcos Bryan
Guimaraes, Ana Marcia Sa
author_facet Zimpel, Cristina Kraemer
Patané, José Salvatore L.
Guedes, Aureliano Coelho Proença
de Souza, Robson F.
Silva-Pereira, Taiana T.
Camargo, Naila C. Soler
de Souza Filho, Antônio F.
Ikuta, Cássia Y.
Neto, José Soares Ferreira
Setubal, João Carlos
Heinemann, Marcos Bryan
Guimaraes, Ana Marcia Sa
author_sort Zimpel, Cristina Kraemer
collection PubMed
description Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains based on limited DNA markers (a.k.a. clonal complexes), and the evolution and ecology of this pathogen has been only marginally explored at the global level. We have screened over 2,600 publicly available M. bovis genomes and newly sequenced four wildlife M. bovis strains, gathering 1,969 genomes from 23 countries and at least 24 host species, including humans, to complete a phylogenomic analyses. We propose the existence of four distinct global lineages of M. bovis (Lb1, Lb2, Lb3, and Lb4) underlying the current disease distribution. These lineages are not fully represented by clonal complexes and are dispersed based on geographic location rather than host species. Our data divergence analysis agreed with previous studies reporting independent archeological data of ancient M. bovis (South Siberian infected skeletons at ∼2,000 years before present) and indicates that extant M. bovis originated between 715 and 3,556 years BP, with later emergence in the New World and Oceania, likely influenced by trades among countries.
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spelling pubmed-72325592020-05-29 Global Distribution and Evolution of Mycobacterium bovis Lineages Zimpel, Cristina Kraemer Patané, José Salvatore L. Guedes, Aureliano Coelho Proença de Souza, Robson F. Silva-Pereira, Taiana T. Camargo, Naila C. Soler de Souza Filho, Antônio F. Ikuta, Cássia Y. Neto, José Soares Ferreira Setubal, João Carlos Heinemann, Marcos Bryan Guimaraes, Ana Marcia Sa Front Microbiol Microbiology Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains based on limited DNA markers (a.k.a. clonal complexes), and the evolution and ecology of this pathogen has been only marginally explored at the global level. We have screened over 2,600 publicly available M. bovis genomes and newly sequenced four wildlife M. bovis strains, gathering 1,969 genomes from 23 countries and at least 24 host species, including humans, to complete a phylogenomic analyses. We propose the existence of four distinct global lineages of M. bovis (Lb1, Lb2, Lb3, and Lb4) underlying the current disease distribution. These lineages are not fully represented by clonal complexes and are dispersed based on geographic location rather than host species. Our data divergence analysis agreed with previous studies reporting independent archeological data of ancient M. bovis (South Siberian infected skeletons at ∼2,000 years before present) and indicates that extant M. bovis originated between 715 and 3,556 years BP, with later emergence in the New World and Oceania, likely influenced by trades among countries. Frontiers Media S.A. 2020-05-07 /pmc/articles/PMC7232559/ /pubmed/32477295 http://dx.doi.org/10.3389/fmicb.2020.00843 Text en Copyright © 2020 Zimpel, Patané, Guedes, de Souza, Silva-Pereira, Camargo, de Souza Filho, Ikuta, Neto, Setubal, Heinemann and Guimaraes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zimpel, Cristina Kraemer
Patané, José Salvatore L.
Guedes, Aureliano Coelho Proença
de Souza, Robson F.
Silva-Pereira, Taiana T.
Camargo, Naila C. Soler
de Souza Filho, Antônio F.
Ikuta, Cássia Y.
Neto, José Soares Ferreira
Setubal, João Carlos
Heinemann, Marcos Bryan
Guimaraes, Ana Marcia Sa
Global Distribution and Evolution of Mycobacterium bovis Lineages
title Global Distribution and Evolution of Mycobacterium bovis Lineages
title_full Global Distribution and Evolution of Mycobacterium bovis Lineages
title_fullStr Global Distribution and Evolution of Mycobacterium bovis Lineages
title_full_unstemmed Global Distribution and Evolution of Mycobacterium bovis Lineages
title_short Global Distribution and Evolution of Mycobacterium bovis Lineages
title_sort global distribution and evolution of mycobacterium bovis lineages
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232559/
https://www.ncbi.nlm.nih.gov/pubmed/32477295
http://dx.doi.org/10.3389/fmicb.2020.00843
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