Gender Differences in Neurodegeneration, Neuroinflammation and Na(+)-Ca(2+) Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease

Twelve-month-old male mice expressing the human A53T variant of α-synuclein (A53T) develop dopamine neuron degeneration, neuroinflammation, and motor deficits, along with dysfunctions of the mitochondrial Na(+)-Ca(2+) exchanger (NCX) isoforms 1 (NCX1) and 3 (NCX3) in the nigrostriatal system. Since...

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Detalles Bibliográficos
Autores principales: Costa, Giulia, Sisalli, Maria Jose, Simola, Nicola, Della Notte, Salvatore, Casu, Maria Antonietta, Serra, Marcello, Pinna, Annalisa, Feliciello, Antonio, Annunziato, Lucio, Scorziello, Antonella, Morelli, Micaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232579/
https://www.ncbi.nlm.nih.gov/pubmed/32477098
http://dx.doi.org/10.3389/fnagi.2020.00118

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