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Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome

INTRODUCTION: Thromboembolism is one of the most serious complications associated with coil embolization therapy. AIM: To identify predisposing factors for thromboembolic complications, as well as to determine whether thromboembolism has an impact on clinical outcome. MATERIAL AND METHODS: From Febr...

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Autores principales: Kocur, Damian, Paździora, Piotr, Przybyłko, Nikodem, Kukier, Wojciech, Baron, Jan, Rudnik, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233158/
https://www.ncbi.nlm.nih.gov/pubmed/32489493
http://dx.doi.org/10.5114/wiitm.2019.89118
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author Kocur, Damian
Paździora, Piotr
Przybyłko, Nikodem
Kukier, Wojciech
Baron, Jan
Rudnik, Adam
author_facet Kocur, Damian
Paździora, Piotr
Przybyłko, Nikodem
Kukier, Wojciech
Baron, Jan
Rudnik, Adam
author_sort Kocur, Damian
collection PubMed
description INTRODUCTION: Thromboembolism is one of the most serious complications associated with coil embolization therapy. AIM: To identify predisposing factors for thromboembolic complications, as well as to determine whether thromboembolism has an impact on clinical outcome. MATERIAL AND METHODS: From February 2008 to March 2015, 273 consecutive patients were treated at our institution via endovascular coil embolization. Patient medical records were reviewed with an emphasis on procedure description, potential risk factors and clinical outcomes related to thromboembolism. Thromboembolic incidents occurred in 19 (6.9%) cases. Multivariate logistic regression models were used to determine independent predictors of thromboembolism. Clinical outcome was analyzed using the Glasgow Outcome Scale (GOS). RESULTS: Multivariate analysis showed that subarachnoid hemorrhage was an independent risk factor for thromboembolic complications (p = 0.003; OR = 4.4; 95% CI: 1.67–12.02). The difference in frequency of perioperative mortality (GOS 1) in patients with thromboembolism and without thromboembolism was not statistically significant (p = 0.22). The differences in frequencies of severe disability (GOS 2–3) and moderate to low disability (GOS 4–5) between patients with thromboembolism and without thromboembolism were statistically significant in the general study population (p < 0.05). CONCLUSIONS: Subarachnoid hemorrhage is an independent predictor of thromboembolic complications associated with endovascular coiling of cerebral aneurysms. Thromboembolism is associated with significantly increased risk of morbidity, and it affects to a certain extent the periprocedural mortality.
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spelling pubmed-72331582020-06-01 Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome Kocur, Damian Paździora, Piotr Przybyłko, Nikodem Kukier, Wojciech Baron, Jan Rudnik, Adam Wideochir Inne Tech Maloinwazyjne Original Paper INTRODUCTION: Thromboembolism is one of the most serious complications associated with coil embolization therapy. AIM: To identify predisposing factors for thromboembolic complications, as well as to determine whether thromboembolism has an impact on clinical outcome. MATERIAL AND METHODS: From February 2008 to March 2015, 273 consecutive patients were treated at our institution via endovascular coil embolization. Patient medical records were reviewed with an emphasis on procedure description, potential risk factors and clinical outcomes related to thromboembolism. Thromboembolic incidents occurred in 19 (6.9%) cases. Multivariate logistic regression models were used to determine independent predictors of thromboembolism. Clinical outcome was analyzed using the Glasgow Outcome Scale (GOS). RESULTS: Multivariate analysis showed that subarachnoid hemorrhage was an independent risk factor for thromboembolic complications (p = 0.003; OR = 4.4; 95% CI: 1.67–12.02). The difference in frequency of perioperative mortality (GOS 1) in patients with thromboembolism and without thromboembolism was not statistically significant (p = 0.22). The differences in frequencies of severe disability (GOS 2–3) and moderate to low disability (GOS 4–5) between patients with thromboembolism and without thromboembolism were statistically significant in the general study population (p < 0.05). CONCLUSIONS: Subarachnoid hemorrhage is an independent predictor of thromboembolic complications associated with endovascular coiling of cerebral aneurysms. Thromboembolism is associated with significantly increased risk of morbidity, and it affects to a certain extent the periprocedural mortality. Termedia Publishing House 2019-10-17 2020-06 /pmc/articles/PMC7233158/ /pubmed/32489493 http://dx.doi.org/10.5114/wiitm.2019.89118 Text en Copyright: © 2019 Fundacja Videochirurgii http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Kocur, Damian
Paździora, Piotr
Przybyłko, Nikodem
Kukier, Wojciech
Baron, Jan
Rudnik, Adam
Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title_full Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title_fullStr Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title_full_unstemmed Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title_short Thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
title_sort thromboembolism during coiling of intracranial aneurysms: predictors and clinical outcome
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233158/
https://www.ncbi.nlm.nih.gov/pubmed/32489493
http://dx.doi.org/10.5114/wiitm.2019.89118
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