Mendelian non-syndromic obesity

Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose...

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Detalles Bibliográficos
Autores principales: Paolacci, Stefano, Pompucci, Giuseppe, Paolini, Barbara, Del Ciondolo, Irene, Miggiano, Giacinto Abele Donato, Aquilanti, Barbara, Scaramuzza, Andrea, Velluti, Valeria, Matera, Giuseppina, Gagliardi, Lucilla, Bertelli, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233639/
https://www.ncbi.nlm.nih.gov/pubmed/31577261
http://dx.doi.org/10.23750/abm.v90i10-S.8766
Descripción
Sumario:Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis. (www.actabiomedica.it)

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