Mendelian non-syndromic obesity

Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose...

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Autores principales: Paolacci, Stefano, Pompucci, Giuseppe, Paolini, Barbara, Del Ciondolo, Irene, Miggiano, Giacinto Abele Donato, Aquilanti, Barbara, Scaramuzza, Andrea, Velluti, Valeria, Matera, Giuseppina, Gagliardi, Lucilla, Bertelli, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233639/
https://www.ncbi.nlm.nih.gov/pubmed/31577261
http://dx.doi.org/10.23750/abm.v90i10-S.8766
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author Paolacci, Stefano
Pompucci, Giuseppe
Paolini, Barbara
Del Ciondolo, Irene
Miggiano, Giacinto Abele Donato
Aquilanti, Barbara
Scaramuzza, Andrea
Velluti, Valeria
Matera, Giuseppina
Gagliardi, Lucilla
Bertelli, Matteo
author_facet Paolacci, Stefano
Pompucci, Giuseppe
Paolini, Barbara
Del Ciondolo, Irene
Miggiano, Giacinto Abele Donato
Aquilanti, Barbara
Scaramuzza, Andrea
Velluti, Valeria
Matera, Giuseppina
Gagliardi, Lucilla
Bertelli, Matteo
author_sort Paolacci, Stefano
collection PubMed
description Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis. (www.actabiomedica.it)
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spelling pubmed-72336392020-05-19 Mendelian non-syndromic obesity Paolacci, Stefano Pompucci, Giuseppe Paolini, Barbara Del Ciondolo, Irene Miggiano, Giacinto Abele Donato Aquilanti, Barbara Scaramuzza, Andrea Velluti, Valeria Matera, Giuseppina Gagliardi, Lucilla Bertelli, Matteo Acta Biomed Review Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis. (www.actabiomedica.it) Mattioli 1885 2019 2019-09-30 /pmc/articles/PMC7233639/ /pubmed/31577261 http://dx.doi.org/10.23750/abm.v90i10-S.8766 Text en Copyright: © 2019 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Review
Paolacci, Stefano
Pompucci, Giuseppe
Paolini, Barbara
Del Ciondolo, Irene
Miggiano, Giacinto Abele Donato
Aquilanti, Barbara
Scaramuzza, Andrea
Velluti, Valeria
Matera, Giuseppina
Gagliardi, Lucilla
Bertelli, Matteo
Mendelian non-syndromic obesity
title Mendelian non-syndromic obesity
title_full Mendelian non-syndromic obesity
title_fullStr Mendelian non-syndromic obesity
title_full_unstemmed Mendelian non-syndromic obesity
title_short Mendelian non-syndromic obesity
title_sort mendelian non-syndromic obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233639/
https://www.ncbi.nlm.nih.gov/pubmed/31577261
http://dx.doi.org/10.23750/abm.v90i10-S.8766
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