Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2

Ectopic expression in T-cell precursors of LIM only protein 2 (LMO2), a key factor in hematopoietic development, has been linked to the onset of T-cell acute lymphoblastic leukaemia (T-ALL). In the T-ALL context, LMO2 drives oncogenic progression through binding to erythroid-specific transcription f...

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Detalles Bibliográficos
Autores principales: Milton-Harris, Leanne, Jeeves, Mark, Walker, Sarah A., Ward, Simon E., Mancini, Erika J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233811/
https://www.ncbi.nlm.nih.gov/pubmed/32477463
http://dx.doi.org/10.18632/oncotarget.27580

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