Priapism in a 28-year-old Male with Bipolar Disorder

Priapism is a serious but rare side effect of psychiatric medications. We report the case of a 28-year-old male who has been mentally stable for a year on a combination of sertraline, olanzapine, and quetiapine. Two weeks after he was started on topiramate, the patient experienced priapism that led to a medical admission and surgical intervention. This case report suggests that topiramate might induce ischemic priapism, either directly or through interactions with other medications. Further studies are warranted to establish such a link.