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DNA methylation, environmental exposures and early embryo development

The first crucial step in the developmental program occurs during pre-implantation, the time after the oocyte has been fertilized and before the embryo implants in the uterus. This period represents a vulnerable window as the epigenome undergoes dynamic changes in DNA methylation profiles. Alteratio...

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Autores principales: Breton-Larrivée, Mélanie, Elder, Elizabeth, McGraw, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Reprodução Animal - CBRA 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234019/
https://www.ncbi.nlm.nih.gov/pubmed/32435290
http://dx.doi.org/10.21451/1984-3143-AR2019-0062
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author Breton-Larrivée, Mélanie
Elder, Elizabeth
McGraw, Serge
author_facet Breton-Larrivée, Mélanie
Elder, Elizabeth
McGraw, Serge
author_sort Breton-Larrivée, Mélanie
collection PubMed
description The first crucial step in the developmental program occurs during pre-implantation, the time after the oocyte has been fertilized and before the embryo implants in the uterus. This period represents a vulnerable window as the epigenome undergoes dynamic changes in DNA methylation profiles. Alterations in the early embryonic reprogramming wave can impair DNA methylation patterns and induce permanent changes to the developmental program, leading to the onset of adverse health outcomes in offspring. Although there is an increasing body of evidence indicating that harmful exposures during pre-implantation embryo development can trigger lasting epigenetic alterations in offspring, the mechanisms are still not fully understood. Since physiological or pathological changes in DNA methylation can occur as a response to environmental cues, proper environmental milieu plays a critical role in the success of embryonic development. In this review, we depict the mechanisms behind the embryonic epigenetic reprogramming of DNA methylation and highlight how maternal environmental stressors (e.g., alcohol, heat stress, nutrient availability) during pre-implantation and assisted reproductive technology procedures affect development and DNA methylation marks.
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spelling pubmed-72340192020-05-20 DNA methylation, environmental exposures and early embryo development Breton-Larrivée, Mélanie Elder, Elizabeth McGraw, Serge Anim Reprod Congress Paper The first crucial step in the developmental program occurs during pre-implantation, the time after the oocyte has been fertilized and before the embryo implants in the uterus. This period represents a vulnerable window as the epigenome undergoes dynamic changes in DNA methylation profiles. Alterations in the early embryonic reprogramming wave can impair DNA methylation patterns and induce permanent changes to the developmental program, leading to the onset of adverse health outcomes in offspring. Although there is an increasing body of evidence indicating that harmful exposures during pre-implantation embryo development can trigger lasting epigenetic alterations in offspring, the mechanisms are still not fully understood. Since physiological or pathological changes in DNA methylation can occur as a response to environmental cues, proper environmental milieu plays a critical role in the success of embryonic development. In this review, we depict the mechanisms behind the embryonic epigenetic reprogramming of DNA methylation and highlight how maternal environmental stressors (e.g., alcohol, heat stress, nutrient availability) during pre-implantation and assisted reproductive technology procedures affect development and DNA methylation marks. Colégio Brasileiro de Reprodução Animal - CBRA 2019-10-23 /pmc/articles/PMC7234019/ /pubmed/32435290 http://dx.doi.org/10.21451/1984-3143-AR2019-0062 Text en Copyright © The Author(s). Published by CBRA. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article under the Creative Commons Attribution License (CC BY 4.0 license)
spellingShingle Congress Paper
Breton-Larrivée, Mélanie
Elder, Elizabeth
McGraw, Serge
DNA methylation, environmental exposures and early embryo development
title DNA methylation, environmental exposures and early embryo development
title_full DNA methylation, environmental exposures and early embryo development
title_fullStr DNA methylation, environmental exposures and early embryo development
title_full_unstemmed DNA methylation, environmental exposures and early embryo development
title_short DNA methylation, environmental exposures and early embryo development
title_sort dna methylation, environmental exposures and early embryo development
topic Congress Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234019/
https://www.ncbi.nlm.nih.gov/pubmed/32435290
http://dx.doi.org/10.21451/1984-3143-AR2019-0062
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