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Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation

Capecitabine, a prodrug of fluorouracil, is a component of many chemotherapy regimens used to treat a wide variety of malignancies. One of the most common adverse reactions experienced by those who have been exposed to capecitabine is palmar-plantar erythrodysesthesia (PPE). PPE is a cutaneous manif...

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Autores principales: Dricken, Julie, Pettke, Erica, Griffin, John A, Li, Henry Y, Mehta, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234053/
https://www.ncbi.nlm.nih.gov/pubmed/32432002
http://dx.doi.org/10.7759/cureus.7724
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author Dricken, Julie
Pettke, Erica
Griffin, John A
Li, Henry Y
Mehta, Vivek
author_facet Dricken, Julie
Pettke, Erica
Griffin, John A
Li, Henry Y
Mehta, Vivek
author_sort Dricken, Julie
collection PubMed
description Capecitabine, a prodrug of fluorouracil, is a component of many chemotherapy regimens used to treat a wide variety of malignancies. One of the most common adverse reactions experienced by those who have been exposed to capecitabine is palmar-plantar erythrodysesthesia (PPE). PPE is a cutaneous manifestation of chemotherapy-related drug toxicity that has signs and symptoms of erythema, edema, pain, ulceration, or desquamation of the palms of the hands and soles of the feet. The signs and symptoms occur with varying severity. There are few reports of the genitalia being similarly affected. The following case describes a patient with locally advanced rectal cancer who experienced erythrodysesthesia secondary to a capecitabine-containing neoadjuvant chemoradiation regimen that primarily and most significantly involved the genitalia. 
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spelling pubmed-72340532020-05-19 Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation Dricken, Julie Pettke, Erica Griffin, John A Li, Henry Y Mehta, Vivek Cureus Dermatology Capecitabine, a prodrug of fluorouracil, is a component of many chemotherapy regimens used to treat a wide variety of malignancies. One of the most common adverse reactions experienced by those who have been exposed to capecitabine is palmar-plantar erythrodysesthesia (PPE). PPE is a cutaneous manifestation of chemotherapy-related drug toxicity that has signs and symptoms of erythema, edema, pain, ulceration, or desquamation of the palms of the hands and soles of the feet. The signs and symptoms occur with varying severity. There are few reports of the genitalia being similarly affected. The following case describes a patient with locally advanced rectal cancer who experienced erythrodysesthesia secondary to a capecitabine-containing neoadjuvant chemoradiation regimen that primarily and most significantly involved the genitalia.  Cureus 2020-04-18 /pmc/articles/PMC7234053/ /pubmed/32432002 http://dx.doi.org/10.7759/cureus.7724 Text en Copyright © 2020, Dricken et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Dricken, Julie
Pettke, Erica
Griffin, John A
Li, Henry Y
Mehta, Vivek
Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title_full Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title_fullStr Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title_full_unstemmed Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title_short Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation
title_sort scrotal and penile erythrodysesthesia associated with neoadjuvant capecitabine chemoradiation
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234053/
https://www.ncbi.nlm.nih.gov/pubmed/32432002
http://dx.doi.org/10.7759/cureus.7724
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