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M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?

BACKGROUND: Hallucinations are the most common and debilitating symptom in schizophrenia, affecting more than 70% of patients. The superior temporal sulcus (STS) is involved in the language process notably in the perception of the human voice and several studies show its implication in auditory verb...

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Autores principales: Lerosier, Baptiste, Dollfus, Sonia, Takerkart, Sylvain, Auzias, Guillaume, Etard, Olivier, Simon, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234135/
http://dx.doi.org/10.1093/schbul/sbaa030.327
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author Lerosier, Baptiste
Dollfus, Sonia
Takerkart, Sylvain
Auzias, Guillaume
Etard, Olivier
Simon, Gregory
author_facet Lerosier, Baptiste
Dollfus, Sonia
Takerkart, Sylvain
Auzias, Guillaume
Etard, Olivier
Simon, Gregory
author_sort Lerosier, Baptiste
collection PubMed
description BACKGROUND: Hallucinations are the most common and debilitating symptom in schizophrenia, affecting more than 70% of patients. The superior temporal sulcus (STS) is involved in the language process notably in the perception of the human voice and several studies show its implication in auditory verbal hallucinations (AVHs). Sulcal patterns in the white matter can reflect an early vulnerability, probably genetic since they set up at a very early stage and are stable over the life course. In contrast, the cortical thickness is dynamic and variable over the development and so can reflect the impact of environmental factors on the maturation of the brain. The aim of this study is therefore to determine whether AVHs are associated with morphological changes of the STS and in particular, whether these changes concern sulcal patterns or cortical thickness reflecting early (genetic) or late (environmental) vulnerability respectively. METHODS: Seventy-three schizophrenia patients (DSM-IV) with a proneness of AVH (53 AVH+) and without AVH (20 AVH-) and 100 healthy volunteers (HC) had a 3T MRI brain scan. Cortical reconstructions were generated using Freesurfer. Mean cortical thickness was measured over the entire brain in each participant. Number of sulcal pits, which represents the position with the maximum depth in the sulcus, was automatically counted on the white matter surface. Both measures were compared between groups and related to the Auditory Hallucination Rating Scale (AHRS). RESULTS: AVH+ patients compared to HC showed a significantly thinner cortical thickness in the left temporal and frontal regions and especially in the STS (p ≤ 0.05 FDR corrected). A negative correlation (r²=0.25) between the cortical thickness in the central part of the left STS and the AHRS score was found (p = 0.01 uncorrected). A different distribution of the number of pits in the left STS is found in AVH+ patients compared to HC (p = 0.05). DISCUSSION: The results suggest that AVH+ patients compared to HC have a lower cortical thickness in the left STS, but also have a specific white matter pattern of the left STS. These results support the hypothesis that a particular morphology of the STS related with auditory hallucinations might be due to both early (genetic) and late (environmental) factors.
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spelling pubmed-72341352020-05-23 M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY? Lerosier, Baptiste Dollfus, Sonia Takerkart, Sylvain Auzias, Guillaume Etard, Olivier Simon, Gregory Schizophr Bull Poster Session II BACKGROUND: Hallucinations are the most common and debilitating symptom in schizophrenia, affecting more than 70% of patients. The superior temporal sulcus (STS) is involved in the language process notably in the perception of the human voice and several studies show its implication in auditory verbal hallucinations (AVHs). Sulcal patterns in the white matter can reflect an early vulnerability, probably genetic since they set up at a very early stage and are stable over the life course. In contrast, the cortical thickness is dynamic and variable over the development and so can reflect the impact of environmental factors on the maturation of the brain. The aim of this study is therefore to determine whether AVHs are associated with morphological changes of the STS and in particular, whether these changes concern sulcal patterns or cortical thickness reflecting early (genetic) or late (environmental) vulnerability respectively. METHODS: Seventy-three schizophrenia patients (DSM-IV) with a proneness of AVH (53 AVH+) and without AVH (20 AVH-) and 100 healthy volunteers (HC) had a 3T MRI brain scan. Cortical reconstructions were generated using Freesurfer. Mean cortical thickness was measured over the entire brain in each participant. Number of sulcal pits, which represents the position with the maximum depth in the sulcus, was automatically counted on the white matter surface. Both measures were compared between groups and related to the Auditory Hallucination Rating Scale (AHRS). RESULTS: AVH+ patients compared to HC showed a significantly thinner cortical thickness in the left temporal and frontal regions and especially in the STS (p ≤ 0.05 FDR corrected). A negative correlation (r²=0.25) between the cortical thickness in the central part of the left STS and the AHRS score was found (p = 0.01 uncorrected). A different distribution of the number of pits in the left STS is found in AVH+ patients compared to HC (p = 0.05). DISCUSSION: The results suggest that AVH+ patients compared to HC have a lower cortical thickness in the left STS, but also have a specific white matter pattern of the left STS. These results support the hypothesis that a particular morphology of the STS related with auditory hallucinations might be due to both early (genetic) and late (environmental) factors. Oxford University Press 2020-05 2020-05-18 /pmc/articles/PMC7234135/ http://dx.doi.org/10.1093/schbul/sbaa030.327 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Session II
Lerosier, Baptiste
Dollfus, Sonia
Takerkart, Sylvain
Auzias, Guillaume
Etard, Olivier
Simon, Gregory
M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title_full M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title_fullStr M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title_full_unstemmed M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title_short M15. MORPHOLOGY OF THE SUPERIOR TEMPORAL SULCUS IN PATIENTS WITH SCHIZOPHRENIA: A MARKER OF GENETIC OR ENVIRONMENTAL VULNERABILITY?
title_sort m15. morphology of the superior temporal sulcus in patients with schizophrenia: a marker of genetic or environmental vulnerability?
topic Poster Session II
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234135/
http://dx.doi.org/10.1093/schbul/sbaa030.327
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