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T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS

BACKGROUND: A great number of studies using resting-state functional MRI (rsfMRI) have been conducted for revealing altered functional connectivity in schizophrenia. Although the default mode network has been predominantly investigated, other resting-state networks (RSNs) can be networks of interest...

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Autores principales: Lee, Jungsun, Joo, Sung Woo, Kim, Harin, Ho Joo, Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234486/
http://dx.doi.org/10.1093/schbul/sbaa029.695
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author Lee, Jungsun
Joo, Sung Woo
Kim, Harin
Ho Joo, Yeon
author_facet Lee, Jungsun
Joo, Sung Woo
Kim, Harin
Ho Joo, Yeon
author_sort Lee, Jungsun
collection PubMed
description BACKGROUND: A great number of studies using resting-state functional MRI (rsfMRI) have been conducted for revealing altered functional connectivity in schizophrenia. Although the default mode network has been predominantly investigated, other resting-state networks (RSNs) can be networks of interest for unveiling the neurobiological basis of schizophrenia. Our study investigated changes in functional connectivity in the nine RSNs in recent-onset schizophrenia. METHODS: We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. In the preprocessing steps, independent component analysis (ICA)-based automatic removal of motion artifacts was applied to eliminate motion-related components from an individual-level ICA. Group ICA and dual regression were performed for voxel-wise comparisons between the groups with the non-parametric permutation test using threshold-free cluster enhancement and a corrected-p < 0.05 for multiple comparisons. We used the Positive and Negative Syndrome Scale scores for the correlation analysis of symptom severity with functional connectivity in the patient group. RESULTS: The control group had areas with a significant group difference in activity compared to that of the patient group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). There were no significant correlations of symptom severity with the functional connectivity of these regions. DISCUSSION: The left supplementary motor cortex, supramarginal gyrus, and right postcentral gyrus having areas with a significant group difference may have a role in the pathophysiology of schizophrenia, given their language and auditory information processing functions.
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spelling pubmed-72344862020-05-23 T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS Lee, Jungsun Joo, Sung Woo Kim, Harin Ho Joo, Yeon Schizophr Bull Poster Session III BACKGROUND: A great number of studies using resting-state functional MRI (rsfMRI) have been conducted for revealing altered functional connectivity in schizophrenia. Although the default mode network has been predominantly investigated, other resting-state networks (RSNs) can be networks of interest for unveiling the neurobiological basis of schizophrenia. Our study investigated changes in functional connectivity in the nine RSNs in recent-onset schizophrenia. METHODS: We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. In the preprocessing steps, independent component analysis (ICA)-based automatic removal of motion artifacts was applied to eliminate motion-related components from an individual-level ICA. Group ICA and dual regression were performed for voxel-wise comparisons between the groups with the non-parametric permutation test using threshold-free cluster enhancement and a corrected-p < 0.05 for multiple comparisons. We used the Positive and Negative Syndrome Scale scores for the correlation analysis of symptom severity with functional connectivity in the patient group. RESULTS: The control group had areas with a significant group difference in activity compared to that of the patient group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). There were no significant correlations of symptom severity with the functional connectivity of these regions. DISCUSSION: The left supplementary motor cortex, supramarginal gyrus, and right postcentral gyrus having areas with a significant group difference may have a role in the pathophysiology of schizophrenia, given their language and auditory information processing functions. Oxford University Press 2020-05 2020-05-18 /pmc/articles/PMC7234486/ http://dx.doi.org/10.1093/schbul/sbaa029.695 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Session III
Lee, Jungsun
Joo, Sung Woo
Kim, Harin
Ho Joo, Yeon
T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title_full T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title_fullStr T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title_full_unstemmed T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title_short T135. ABERRANT EXECUTIVE CONTROL AND AUDITORY NETWORKS IN RECENT-ONSET SCHIZOPHRENIA - A GROUP ICA DUAL REGRESSION ANALYSIS
title_sort t135. aberrant executive control and auditory networks in recent-onset schizophrenia - a group ica dual regression analysis
topic Poster Session III
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234486/
http://dx.doi.org/10.1093/schbul/sbaa029.695
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