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M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG

BACKGROUND: Subjective quality of life (SQoL) is an important outcome domain in patients with early psychosis. In an attempt to better understand and maximize SQoL of early psychosis patients, an increasing number of research has been conducted to investigate factors associated with SQoL. Nonetheles...

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Autores principales: Tze Kwan Kam, Candice, Chun Lau, Fu, Ting Liu, Tsz, Sau Man Wong, Corine, Ming Hui, Lai, Wa Chan, Kit, Ming Lee, Ho, Nam Suen, Yi, Chen, Eric, Chung Chang, Wing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234573/
http://dx.doi.org/10.1093/schbul/sbaa030.508
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author Tze Kwan Kam, Candice
Chun Lau, Fu
Ting Liu, Tsz
Sau Man Wong, Corine
Ming Hui, Lai
Wa Chan, Kit
Ming Lee, Ho
Nam Suen, Yi
Chen, Eric
Chung Chang, Wing
author_facet Tze Kwan Kam, Candice
Chun Lau, Fu
Ting Liu, Tsz
Sau Man Wong, Corine
Ming Hui, Lai
Wa Chan, Kit
Ming Lee, Ho
Nam Suen, Yi
Chen, Eric
Chung Chang, Wing
author_sort Tze Kwan Kam, Candice
collection PubMed
description BACKGROUND: Subjective quality of life (SQoL) is an important outcome domain in patients with early psychosis. In an attempt to better understand and maximize SQoL of early psychosis patients, an increasing number of research has been conducted to investigate factors associated with SQoL. Nonetheless, most previous studies focused on younger patients with early psychosis. In this study, the correlates of SQoL in adult patients who had completed 3-year specialized early intervention service for first-episode psychosis (FEP) in Hong Kong were investigated. METHODS: In total, one hundred and one Chinese patients aged 26–55 years who completed 3-year specialized early intervention service for psychosis in Hong Kong were recruited. Assessments on illness onset (DUP), clinical (PANSS, BNSS, SUMD), intrinsic motivation (by items in Quality of Life Scale, QLS), functional (SOFAS), antipsychotic-induced parkinsonism features (Simpson-Angus Scale, SAS) were conducted. SQoL was evaluated by Chinese version SF-12 which consist of physical and mental components for analysis. RESULTS: Correlation analyses showed that SF12 physical health score was correlated with PANSS depression component (p<0.001), QLS intrinsic motivation score (p=0.001) and SAS score (p<0.05) while SF12 mental health score was correlated with PANSS depression score (p<0.001), QLS intrinsic motivation score (p<0.05) and SAS score (p<0.05). Multiple linear regression analyses further revealed that lower PANSS depression score (p<0.001) and higher intrinsic motivation (measured by QLS, p<0.05) were independently associated with better physical SQoL, while lower PANSS depression score (p<0.001) and lower SAS side-effect score (p<0.05) were independently related to better mental SQoL. DISCUSSION: Our results are consistent with the literature which indicates that SQoL is significantly related to depressive symptoms. In addition, patients with higher intrinsic motivation and less antipsychotic-induced extrapyramidal side-effect have better SQoL. Further analysis on the longitudinal data will clarify variables predictive of SQoL at follow-up.
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spelling pubmed-72345732020-05-23 M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG Tze Kwan Kam, Candice Chun Lau, Fu Ting Liu, Tsz Sau Man Wong, Corine Ming Hui, Lai Wa Chan, Kit Ming Lee, Ho Nam Suen, Yi Chen, Eric Chung Chang, Wing Schizophr Bull Poster Session II BACKGROUND: Subjective quality of life (SQoL) is an important outcome domain in patients with early psychosis. In an attempt to better understand and maximize SQoL of early psychosis patients, an increasing number of research has been conducted to investigate factors associated with SQoL. Nonetheless, most previous studies focused on younger patients with early psychosis. In this study, the correlates of SQoL in adult patients who had completed 3-year specialized early intervention service for first-episode psychosis (FEP) in Hong Kong were investigated. METHODS: In total, one hundred and one Chinese patients aged 26–55 years who completed 3-year specialized early intervention service for psychosis in Hong Kong were recruited. Assessments on illness onset (DUP), clinical (PANSS, BNSS, SUMD), intrinsic motivation (by items in Quality of Life Scale, QLS), functional (SOFAS), antipsychotic-induced parkinsonism features (Simpson-Angus Scale, SAS) were conducted. SQoL was evaluated by Chinese version SF-12 which consist of physical and mental components for analysis. RESULTS: Correlation analyses showed that SF12 physical health score was correlated with PANSS depression component (p<0.001), QLS intrinsic motivation score (p=0.001) and SAS score (p<0.05) while SF12 mental health score was correlated with PANSS depression score (p<0.001), QLS intrinsic motivation score (p<0.05) and SAS score (p<0.05). Multiple linear regression analyses further revealed that lower PANSS depression score (p<0.001) and higher intrinsic motivation (measured by QLS, p<0.05) were independently associated with better physical SQoL, while lower PANSS depression score (p<0.001) and lower SAS side-effect score (p<0.05) were independently related to better mental SQoL. DISCUSSION: Our results are consistent with the literature which indicates that SQoL is significantly related to depressive symptoms. In addition, patients with higher intrinsic motivation and less antipsychotic-induced extrapyramidal side-effect have better SQoL. Further analysis on the longitudinal data will clarify variables predictive of SQoL at follow-up. Oxford University Press 2020-05 2020-05-18 /pmc/articles/PMC7234573/ http://dx.doi.org/10.1093/schbul/sbaa030.508 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Session II
Tze Kwan Kam, Candice
Chun Lau, Fu
Ting Liu, Tsz
Sau Man Wong, Corine
Ming Hui, Lai
Wa Chan, Kit
Ming Lee, Ho
Nam Suen, Yi
Chen, Eric
Chung Chang, Wing
M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title_full M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title_fullStr M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title_full_unstemmed M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title_short M196. CLINICAL CORRELATES OF SUBJECTIVE QUALITY OF LIFE IN ADULT PATIENTS WITH EARLY PSYCHOSIS IN HONG KONG
title_sort m196. clinical correlates of subjective quality of life in adult patients with early psychosis in hong kong
topic Poster Session II
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234573/
http://dx.doi.org/10.1093/schbul/sbaa030.508
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