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Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review

INTRODUCTION: Proper strategies to minimise the risk of infection in individuals handling the bodies of deceased persons infected with 2019 novel coronavirus (2019-nCoV) are urgently needed. The objective of this study was to systematically review the literature to scope and assess the effects of sp...

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Autores principales: Yaacoub, Sally, Schünemann, Holger J, Khabsa, Joanne, El-Harakeh, Amena, Khamis, Assem M, Chamseddine, Fatimah, El Khoury, Rayane, Saad, Zahra, Hneiny, Layal, Cuello Garcia, Carlos, Muti-Schünemann, Giovanna Elsa Ute, Bognanni, Antonio, Chen, Chen, Chen, Guang, Zhang, Yuan, Zhao, Hong, Abi Hanna, Pierre, Loeb, Mark, Piggott, Thomas, Reinap, Marge, Rizk, Nesrine, Stalteri, Rosa, Duda, Stephanie, Solo, Karla, Chu, Derek K, Akl, Elie A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234869/
https://www.ncbi.nlm.nih.gov/pubmed/32409328
http://dx.doi.org/10.1136/bmjgh-2020-002650
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author Yaacoub, Sally
Schünemann, Holger J
Khabsa, Joanne
El-Harakeh, Amena
Khamis, Assem M
Chamseddine, Fatimah
El Khoury, Rayane
Saad, Zahra
Hneiny, Layal
Cuello Garcia, Carlos
Muti-Schünemann, Giovanna Elsa Ute
Bognanni, Antonio
Chen, Chen
Chen, Guang
Zhang, Yuan
Zhao, Hong
Abi Hanna, Pierre
Loeb, Mark
Piggott, Thomas
Reinap, Marge
Rizk, Nesrine
Stalteri, Rosa
Duda, Stephanie
Solo, Karla
Chu, Derek K
Akl, Elie A
author_facet Yaacoub, Sally
Schünemann, Holger J
Khabsa, Joanne
El-Harakeh, Amena
Khamis, Assem M
Chamseddine, Fatimah
El Khoury, Rayane
Saad, Zahra
Hneiny, Layal
Cuello Garcia, Carlos
Muti-Schünemann, Giovanna Elsa Ute
Bognanni, Antonio
Chen, Chen
Chen, Guang
Zhang, Yuan
Zhao, Hong
Abi Hanna, Pierre
Loeb, Mark
Piggott, Thomas
Reinap, Marge
Rizk, Nesrine
Stalteri, Rosa
Duda, Stephanie
Solo, Karla
Chu, Derek K
Akl, Elie A
author_sort Yaacoub, Sally
collection PubMed
description INTRODUCTION: Proper strategies to minimise the risk of infection in individuals handling the bodies of deceased persons infected with 2019 novel coronavirus (2019-nCoV) are urgently needed. The objective of this study was to systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies. METHODS: We searched five general, three Chinese and four coronavirus disease (COVID-19)–specific electronic databases. We searched registries of clinical trials, websites of governmental and other relevant organisations, reference lists of the included papers and relevant systematic reviews, and Epistemonikos for relevant systematic reviews. We included guidance documents providing practical advice on the handling of bodies of deceased persons with suspected or confirmed COVID-19. Then, we sought primary evidence of any study design reporting on the efficacy and safety of the identified strategies in coronaviruses. We included evidence relevant to contextual factors (ie, acceptability). A single reviewer extracted data using a pilot-tested form and graded the certainty of the evidence using the GRADE approach. A second reviewer verified the data and assessments. RESULTS: We identified one study proposing an uncommon strategy for autopsies for patients with severe acute respiratory syndrome. The study provided very low-certainty evidence that it reduced the risk of transmission. We identified 23 guidance documents providing practical advice on the steps of handling the bodies: preparation, packing, and others and advice related to both the handling of the dead bodies and the use of personal protective equipment by individuals handling them. We did not identify COVID-19 evidence relevant to any of these steps. CONCLUSION: While a substantive number of guidance documents propose specific strategies, we identified no study providing direct evidence for the effects of any of those strategies. While this review highlights major research gaps, it allows interested entities to build their own guidance.
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spelling pubmed-72348692020-05-19 Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review Yaacoub, Sally Schünemann, Holger J Khabsa, Joanne El-Harakeh, Amena Khamis, Assem M Chamseddine, Fatimah El Khoury, Rayane Saad, Zahra Hneiny, Layal Cuello Garcia, Carlos Muti-Schünemann, Giovanna Elsa Ute Bognanni, Antonio Chen, Chen Chen, Guang Zhang, Yuan Zhao, Hong Abi Hanna, Pierre Loeb, Mark Piggott, Thomas Reinap, Marge Rizk, Nesrine Stalteri, Rosa Duda, Stephanie Solo, Karla Chu, Derek K Akl, Elie A BMJ Glob Health Original Research INTRODUCTION: Proper strategies to minimise the risk of infection in individuals handling the bodies of deceased persons infected with 2019 novel coronavirus (2019-nCoV) are urgently needed. The objective of this study was to systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies. METHODS: We searched five general, three Chinese and four coronavirus disease (COVID-19)–specific electronic databases. We searched registries of clinical trials, websites of governmental and other relevant organisations, reference lists of the included papers and relevant systematic reviews, and Epistemonikos for relevant systematic reviews. We included guidance documents providing practical advice on the handling of bodies of deceased persons with suspected or confirmed COVID-19. Then, we sought primary evidence of any study design reporting on the efficacy and safety of the identified strategies in coronaviruses. We included evidence relevant to contextual factors (ie, acceptability). A single reviewer extracted data using a pilot-tested form and graded the certainty of the evidence using the GRADE approach. A second reviewer verified the data and assessments. RESULTS: We identified one study proposing an uncommon strategy for autopsies for patients with severe acute respiratory syndrome. The study provided very low-certainty evidence that it reduced the risk of transmission. We identified 23 guidance documents providing practical advice on the steps of handling the bodies: preparation, packing, and others and advice related to both the handling of the dead bodies and the use of personal protective equipment by individuals handling them. We did not identify COVID-19 evidence relevant to any of these steps. CONCLUSION: While a substantive number of guidance documents propose specific strategies, we identified no study providing direct evidence for the effects of any of those strategies. While this review highlights major research gaps, it allows interested entities to build their own guidance. BMJ Publishing Group 2020-05-14 /pmc/articles/PMC7234869/ /pubmed/32409328 http://dx.doi.org/10.1136/bmjgh-2020-002650 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Yaacoub, Sally
Schünemann, Holger J
Khabsa, Joanne
El-Harakeh, Amena
Khamis, Assem M
Chamseddine, Fatimah
El Khoury, Rayane
Saad, Zahra
Hneiny, Layal
Cuello Garcia, Carlos
Muti-Schünemann, Giovanna Elsa Ute
Bognanni, Antonio
Chen, Chen
Chen, Guang
Zhang, Yuan
Zhao, Hong
Abi Hanna, Pierre
Loeb, Mark
Piggott, Thomas
Reinap, Marge
Rizk, Nesrine
Stalteri, Rosa
Duda, Stephanie
Solo, Karla
Chu, Derek K
Akl, Elie A
Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title_full Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title_fullStr Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title_full_unstemmed Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title_short Safe management of bodies of deceased persons with suspected or confirmed COVID-19: a rapid systematic review
title_sort safe management of bodies of deceased persons with suspected or confirmed covid-19: a rapid systematic review
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234869/
https://www.ncbi.nlm.nih.gov/pubmed/32409328
http://dx.doi.org/10.1136/bmjgh-2020-002650
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