The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases

Current studies have confirmed that liver diseases are closely related to intestinal microorganisms; however, those studies have mainly concentrated on bacteria. Although the proportion of intestinal microorganisms accounted for by colonizing fungi is very small, these fungi do have a significant ef...

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Autores principales: You, Ningning, Zhuo, Lili, Zhou, Jingxin, Song, Yu, Shi, Junping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234879/
https://www.ncbi.nlm.nih.gov/pubmed/31554391
http://dx.doi.org/10.5009/gnl18579
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author You, Ningning
Zhuo, Lili
Zhou, Jingxin
Song, Yu
Shi, Junping
author_facet You, Ningning
Zhuo, Lili
Zhou, Jingxin
Song, Yu
Shi, Junping
author_sort You, Ningning
collection PubMed
description Current studies have confirmed that liver diseases are closely related to intestinal microorganisms; however, those studies have mainly concentrated on bacteria. Although the proportion of intestinal microorganisms accounted for by colonizing fungi is very small, these fungi do have a significant effect on the homeostasis of the intestinal microecosystem. In this paper, the characteristics of intestinal fungi in patients with chronic liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease and cirrhosis are summarized, and the effects of intestinal fungi and their metabolites are analyzed and discussed. It is important to realize that not only bacteria but also intestinal fungi play important roles in liver diseases.
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spelling pubmed-72348792020-06-01 The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases You, Ningning Zhuo, Lili Zhou, Jingxin Song, Yu Shi, Junping Gut Liver Review Current studies have confirmed that liver diseases are closely related to intestinal microorganisms; however, those studies have mainly concentrated on bacteria. Although the proportion of intestinal microorganisms accounted for by colonizing fungi is very small, these fungi do have a significant effect on the homeostasis of the intestinal microecosystem. In this paper, the characteristics of intestinal fungi in patients with chronic liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease and cirrhosis are summarized, and the effects of intestinal fungi and their metabolites are analyzed and discussed. It is important to realize that not only bacteria but also intestinal fungi play important roles in liver diseases. Editorial Office of Gut and Liver 2020-05-15 2019-09-30 /pmc/articles/PMC7234879/ /pubmed/31554391 http://dx.doi.org/10.5009/gnl18579 Text en Copyright © 2020 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
You, Ningning
Zhuo, Lili
Zhou, Jingxin
Song, Yu
Shi, Junping
The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title_full The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title_fullStr The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title_full_unstemmed The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title_short The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
title_sort role of intestinal fungi and its metabolites in chronic liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234879/
https://www.ncbi.nlm.nih.gov/pubmed/31554391
http://dx.doi.org/10.5009/gnl18579
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