The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19

Recently observed similarities in COVID-19 susceptibility among genetically related individuals hints at a selectivity of the SARS-CoV-2 virus that hinges on the affinity for select genetic profiles prevalent in the human species. The selectivity determines susceptibility of clinical disease and ext...

Descripción completa

Detalles Bibliográficos
Autor principal: Khan, Fawad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234940/
https://www.ncbi.nlm.nih.gov/pubmed/32483490
http://dx.doi.org/10.1016/j.nmni.2020.100697
_version_ 1783535868296822784
author Khan, Fawad A.
author_facet Khan, Fawad A.
author_sort Khan, Fawad A.
collection PubMed
description Recently observed similarities in COVID-19 susceptibility among genetically related individuals hints at a selectivity of the SARS-CoV-2 virus that hinges on the affinity for select genetic profiles prevalent in the human species. The selectivity determines susceptibility of clinical disease and extent of pathogenesis, including fatal lung and myocardial injury, and may be more cogent than the recently reported risk factors. The selectivity of the SARS-CoV-2 virus for human genetic profiles as a factor of the virulence appears to be a novel feature and was not previously noted in the epidemics of widespread viral respiratory illnesses in humans.
format Online
Article
Text
id pubmed-7234940
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-72349402020-05-19 The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19 Khan, Fawad A. New Microbes New Infect Letter to the Editor Recently observed similarities in COVID-19 susceptibility among genetically related individuals hints at a selectivity of the SARS-CoV-2 virus that hinges on the affinity for select genetic profiles prevalent in the human species. The selectivity determines susceptibility of clinical disease and extent of pathogenesis, including fatal lung and myocardial injury, and may be more cogent than the recently reported risk factors. The selectivity of the SARS-CoV-2 virus for human genetic profiles as a factor of the virulence appears to be a novel feature and was not previously noted in the epidemics of widespread viral respiratory illnesses in humans. Elsevier 2020-05-19 /pmc/articles/PMC7234940/ /pubmed/32483490 http://dx.doi.org/10.1016/j.nmni.2020.100697 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter to the Editor
Khan, Fawad A.
The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title_full The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title_fullStr The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title_full_unstemmed The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title_short The role of selectivity of the SARS-CoV-2 virus for human genetic profiles in susceptibility and resistance to COVID-19
title_sort role of selectivity of the sars-cov-2 virus for human genetic profiles in susceptibility and resistance to covid-19
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234940/
https://www.ncbi.nlm.nih.gov/pubmed/32483490
http://dx.doi.org/10.1016/j.nmni.2020.100697
work_keys_str_mv AT khanfawada theroleofselectivityofthesarscov2virusforhumangeneticprofilesinsusceptibilityandresistancetocovid19
AT khanfawada roleofselectivityofthesarscov2virusforhumangeneticprofilesinsusceptibilityandresistancetocovid19

Ejemplares similares