Cargando…

A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents

BACKGROUND: Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Yongting, Xie, Hong, Sun, Lili, Wang, Bangxuan, Zhang, Li, Han, Hui, Yao, Rongying, Sun, Yehuan, Fu, Lianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234967/
https://www.ncbi.nlm.nih.gov/pubmed/32523365
http://dx.doi.org/10.2147/DMSO.S238224
_version_ 1783535874639659008
author Yuan, Yongting
Xie, Hong
Sun, Lili
Wang, Bangxuan
Zhang, Li
Han, Hui
Yao, Rongying
Sun, Yehuan
Fu, Lianguo
author_facet Yuan, Yongting
Xie, Hong
Sun, Lili
Wang, Bangxuan
Zhang, Li
Han, Hui
Yao, Rongying
Sun, Yehuan
Fu, Lianguo
author_sort Yuan, Yongting
collection PubMed
description BACKGROUND: Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present study was to explore an association between CLAP and impaired fasting glucose (IFG) in Chinese children and adolescents. METHODS: A total of 683 children and adolescents aged 8–15 years were recruited using the stratified cluster sampling method in this cross-sectional study and were measured for body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), fasting plasma glucose, dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic (ROC) curve were used to compare the effects of CLAP for predicting IFG. RESULTS: The prevalence of IFG in children and adolescents was 13.8%: 16.9% in boys and 10.1% in girls (P<0.05). The CLAP, height, weight, WC, AST, waist-to-height ratio (WHtR), and TG among boys with IFG were significantly higher than those among boys without IFG (P<0.05). The area under the ROC curve of CLAP for predicting IFG (0.637 (0.562–0.712)) was higher than those of WC, WHtR, AST, and TG. The cutoff point of P(75) CLAP was the optimal value to predict IFG among boys, and the OR (95% CI) was 2.48 (1.40–4.42) and area under the ROC curve was 0.595 (0.513–0.676). CONCLUSION: The CLAP was a novel indicator associated with IFG in Chinese boys, and it performed better than WC, WHtR, AST and TG.
format Online
Article
Text
id pubmed-7234967
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-72349672020-06-09 A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents Yuan, Yongting Xie, Hong Sun, Lili Wang, Bangxuan Zhang, Li Han, Hui Yao, Rongying Sun, Yehuan Fu, Lianguo Diabetes Metab Syndr Obes Original Research BACKGROUND: Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present study was to explore an association between CLAP and impaired fasting glucose (IFG) in Chinese children and adolescents. METHODS: A total of 683 children and adolescents aged 8–15 years were recruited using the stratified cluster sampling method in this cross-sectional study and were measured for body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), fasting plasma glucose, dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic (ROC) curve were used to compare the effects of CLAP for predicting IFG. RESULTS: The prevalence of IFG in children and adolescents was 13.8%: 16.9% in boys and 10.1% in girls (P<0.05). The CLAP, height, weight, WC, AST, waist-to-height ratio (WHtR), and TG among boys with IFG were significantly higher than those among boys without IFG (P<0.05). The area under the ROC curve of CLAP for predicting IFG (0.637 (0.562–0.712)) was higher than those of WC, WHtR, AST, and TG. The cutoff point of P(75) CLAP was the optimal value to predict IFG among boys, and the OR (95% CI) was 2.48 (1.40–4.42) and area under the ROC curve was 0.595 (0.513–0.676). CONCLUSION: The CLAP was a novel indicator associated with IFG in Chinese boys, and it performed better than WC, WHtR, AST and TG. Dove 2020-05-14 /pmc/articles/PMC7234967/ /pubmed/32523365 http://dx.doi.org/10.2147/DMSO.S238224 Text en © 2020 Yuan et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Yuan, Yongting
Xie, Hong
Sun, Lili
Wang, Bangxuan
Zhang, Li
Han, Hui
Yao, Rongying
Sun, Yehuan
Fu, Lianguo
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title_full A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title_fullStr A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title_full_unstemmed A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title_short A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
title_sort novel indicator of children’s lipid accumulation product associated with impaired fasting glucose in chinese children and adolescents
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234967/
https://www.ncbi.nlm.nih.gov/pubmed/32523365
http://dx.doi.org/10.2147/DMSO.S238224
work_keys_str_mv AT yuanyongting anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT xiehong anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT sunlili anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT wangbangxuan anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT zhangli anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT hanhui anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT yaorongying anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT sunyehuan anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT fulianguo anovelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT yuanyongting novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT xiehong novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT sunlili novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT wangbangxuan novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT zhangli novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT hanhui novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT yaorongying novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT sunyehuan novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents
AT fulianguo novelindicatorofchildrenslipidaccumulationproductassociatedwithimpairedfastingglucoseinchinesechildrenandadolescents